English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Lectin-mediated bacterial modulation by the intestinal nematode Ascaris suum

Midha, A., Goyette-Desjardins, G., Goerdeler, F., Moscovitz, O., Seeberger, P. H., Tedin, K., et al. (2021). Lectin-mediated bacterial modulation by the intestinal nematode Ascaris suum. International Journal of Molecular Sciences, 22(16): 8739. doi:10.3390/ijms22168739.

Item is

Basic

show hide
Genre: Journal Article

Files

show Files
hide Files
:
Article.pdf (Publisher version), 4MB
Name:
Article.pdf
Description:
-
OA-Status:
Gold
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
-

Locators

show

Creators

show
hide
 Creators:
Midha, Ankur, Author
Goyette-Desjardins, Guillaume, Author
Goerdeler, Felix1, Author           
Moscovitz, Oren1, Author           
Seeberger, Peter H.2, Author           
Tedin, Karsten, Author
Bertzbach, Luca D., Author
Lepenies, Bernd, Author
Hartmann, Susanne, Author
Affiliations:
1Oren Moscovitz, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_3176803              
2Peter H. Seeberger - Vaccine Development, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863308              

Content

show
hide
Free keywords: Ascaris; helminths; intestinal nematode; microbiota; lectin; Salmonella; glycan array; C-type lectin; C-type lectin receptor
 Abstract: Ascariasis is a global health problem for humans and animals. Adult Ascaris nematodes are long-lived in the host intestine where they interact with host cells as well as members of the microbiota resulting in chronic infections. Nematode interactions with host cells and the microbial environment are prominently mediated by parasite-secreted proteins and peptides possessing immunomodulatory and antimicrobial activities. Previously, we discovered the C-type lectin protein AsCTL-42 in the secreted products of adult Ascaris worms. Here we tested recombinant AsCTL-42 for its ability to interact with bacterial and host cells. We found that AsCTL-42 lacks bactericidal activity but neutralized bacterial cells without killing them. Treatment of bacterial cells with AsCTL-42 reduced invasion of intestinal epithelial cells by Salmonella. Furthermore, AsCTL-42 interacted with host myeloid C-type lectin receptors. Thus, AsCTL-42 is a parasite protein involved in the triad relationship between Ascaris, host cells, and the microbiota.

Details

show
hide
Language(s): eng - English
 Dates: 2021-08-142021
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.3390/ijms22168739
BibTex Citekey: ijms22168739
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: International Journal of Molecular Sciences
  Abbreviation : Int. J. Mol. Sci.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Basel, Switzerland : MDPI AG
Pages: - Volume / Issue: 22 (16) Sequence Number: 8739 Start / End Page: - Identifier: ISSN: 1422-0067