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  Inside a shell – organometallic catalysis inside encapsulin nanoreactors

Lohner, P., Zmyslia, M., Thurn, J., Pape, J. K., Gerasimaite, R., Keller-Findeisen, J., et al. (2021). Inside a shell – organometallic catalysis inside encapsulin nanoreactors. Angewandte Chemie, 133(44), 24028-24034. doi:10.1002/ange.202110327.

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 Creators:
Lohner, Philipp, Author
Zmyslia, Mariia, Author
Thurn, Johann, Author
Pape, Jasmin K., Author
Gerasimaite, Ruta, Author
Keller-Findeisen, Jan, Author
Groeer, Saskia, Author
Deuringer, Benedikt, Author
Süss, Regine, Author
Walther, Andreas, Author
Hell, Stefan W.1, Author           
Lukinavicius, Grazvydas, Author
Hugel, Thorsten, Author
Jessen-Trefzer, Claudia, Author
Affiliations:
1Department of NanoBiophotonics, MPI for Biophysical Chemistry, Max Planck Society, ou_578627              

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Free keywords: Bioorthogonal chemistry * Self-assembly * Homogeneous catalysis * MINFLUX * Single-molecule FRET
 Abstract: Compartmentalization of chemical reactions inside cells are a fundamental requirement for life. Encapsulins are self-assembling protein-based nanocompartments from the prokaryotic repertoire that present a highly attractive platform for intracellular compartmentalization of chemical reactions by design. Using smFRET and 3D-MINFLUX analysis, we analyze fluorescently-labeled encapsulins on a single molecule basis. Furthermore, by equipping these capsules with a synthetic ruthenium catalyst via covalent attachment to a non-native host protein, we are able to perform in vitro catalysis and go on to show that engineered encapsulins can be used as hosts for transition metal catalysis inside living cells in confined space.

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Language(s): eng - English
 Dates: 2021-08-022021-08-212021-10-012021-10-25
 Publication Status: Issued
 Pages: 7
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Degree: -

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Title: Angewandte Chemie
  Abbreviation : Angew. Chem.
Source Genre: Journal
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Publ. Info: Weinheim : Wiley-VCH
Pages: - Volume / Issue: 133 (44) Sequence Number: - Start / End Page: 24028 - 24034 Identifier: ISSN: 0044-8249
CoNE: https://pure.mpg.de/cone/journals/resource/954926979058_1