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  Pre-activated antiviral innate immunity in the upper airways controls early SARS-CoV-2 infection in children

Loske, J., Röhmel, J., Lukassen, S., Stricker, S., Magalhães, V. G., Liebig, J., et al. (2021). Pre-activated antiviral innate immunity in the upper airways controls early SARS-CoV-2 infection in children. Nature Biotechnology. doi:10.1038/s41587-021-01037-9.

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 Creators:
Loske, J., Author
Röhmel, J., Author
Lukassen, S., Author
Stricker, S., Author
Magalhães, V. G., Author
Liebig, J., Author
Chua, R. L., Author
Thürmann, L., Author
Messingschlager, M., Author
Seegebarth, A., Author
Timmermann, B.1, Author           
Klages, S.1, Author           
Ralser, M., Author
Sawitzki, B., Author
Sander, L. E. , Author
Corman, V. M. , Author
Conrad, C., Author
Laudi, S., Author
Binder, M., Author
Trump, S., Author
Eils, R., AuthorMall, M. A., AuthorLehmann, I., Author more..
Affiliations:
1Sequencing (Head: Bernd Timmermann), Scientific Service (Head: Christoph Krukenkamp), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479670              

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 Abstract: Children have reduced severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection rates and a substantially lower risk for developing severe coronavirus disease 2019 compared with adults. However, the molecular mechanisms underlying protection in younger age groups remain unknown. Here we characterize the single-cell transcriptional landscape in the upper airways of SARS-CoV-2-negative (n = 18) and age-matched SARS-CoV-2-positive (n = 24) children and corresponding samples from adults (n = 44), covering an age range of 4 weeks to 77 years. Children displayed higher basal expression of relevant pattern recognition receptors such as MDA5 (IFIH1) and RIG-I (DDX58) in upper airway epithelial cells, macrophages and dendritic cells, resulting in stronger innate antiviral responses upon SARS-CoV-2 infection than in adults. We further detected distinct immune cell subpopulations including KLRC1 (NKG2A)+ cytotoxic T cells and a CD8+ T cell population with a memory phenotype occurring predominantly in children. Our study provides evidence that the airway immune cells of children are primed for virus sensing, resulting in a stronger early innate antiviral response to SARS-CoV-2 infection than in adults.

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Language(s): eng - English
 Dates: 2021-07-282021-08-18
 Publication Status: Published online
 Pages: -
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 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1038/s41587-021-01037-9
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Title: Nature Biotechnology
  Abbreviation : Nat. Biotechnol.
Source Genre: Journal
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Publ. Info: New York : Gale Group Inc.
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: - Identifier: ISSN: 1087-0156
CoNE: https://pure.mpg.de/cone/journals/resource/954926980065