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  Integrated annotation and analysis of genomic features reveal new types of functional elements and large-scale epigenetic phenomena in the developing zebrafish

Baranasic, D., Hörtenhuber, M., Balwierz, P., Zehnder, T., Mukarram, A. K., Nepal, C., et al. (2021). Integrated annotation and analysis of genomic features reveal new types of functional elements and large-scale epigenetic phenomena in the developing zebrafish. bioRxiv. doi:10.1101/2021.08.09.454869.

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Baranasic_2021.pdf (Preprint), 22MB
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© 2021, The author(s)

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Baranasic, Damir , Autor
Hörtenhuber, Matthias , Autor
Balwierz, Piotr , Autor
Zehnder, Tobias1, Autor           
Mukarram, Abdul Kadir , Autor
Nepal, Chirag , Autor
Varnai, Csilla , Autor
Hadzhiev, Yavor , Autor
Jimenez- Gonzalez, Ada , Autor
Li, Nan, Autor
Wragg, Joseph , Autor
D’Orazio, Fabio, Autor
Díaz, Noelia , Autor
Hernández- Rodríguez, Benjamín , Autor
Chen, Zelin, Autor
Stoiber, Marcus , Autor
Dong, Michaël, Autor
Stevens, Irene, Autor
Ross, Samuel E. , Autor
Eagle, Anne, Autor
Martin, Ryan , AutorObasaju, Pelumi, AutorRastegar, Sepand , AutorMcGarvey, Alison C. , AutorKopp, Wolfgang, AutorChambers, Emily , AutorWang, Dennis, AutorKim, Hyejeong R. , AutorAcemel, Rafael D. , AutorNaranjo, Silvia , AutorLapinski, Maciej , AutorChong, Vanessa , AutorMathavan, Sinnakaruppan , AutorPeers, Bernard, AutorSauka-Spengler, Tatjana, AutorVingron, Martin1, Autor           Carninci, Piero , AutorOhler, Uwe, AutorLacadie, Scott Allen , AutorBurgess, Shawn, AutorWinata, Cecilia , Autorvan Eeden, Freek , AutorVaquerizas, Juan M. , AutorGómez-Skarmeta, José Luis , AutorOnichtchouk, Daria , AutorBrown, Ben James , AutorBogdanovic, Ozren , AutorWesterfield, Monte , AutorWardle, Fiona C. , AutorDaub, Carsten O. , AutorLenhard, Boris , AutorMüller, Ferenc, Autor mehr..
Affiliations:
1Transcriptional Regulation (Martin Vingron), Dept. of Computational Molecular Biology (Head: Martin Vingron), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479639              

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 Zusammenfassung: Zebrafish, a popular model for embryonic development and for modelling human diseases, has so far lacked a systematic functional annotation programme akin to those in other animal models. To address this, we formed the international DANIO-CODE consortium and created the first central repository to store and process zebrafish developmental functional genomic data. Our Data Coordination Center (https://danio-code.zfin.org) combines a total of 1,802 sets of unpublished and reanalysed published genomics data, which we used to improve existing annotations and show its utility in experimental design. We identified over 140,000 cis-regulatory elements in development, including novel classes with distinct features dependent on their activity in time and space. We delineated the distinction between regulatory elements active during zygotic genome activation and those active during organogenesis, identifying new aspects of how they relate to each other. Finally, we matched regulatory elements and epigenomic landscapes between zebrafish and mouse and predict functional relationships between them beyond sequence similarity, extending the utility of zebrafish developmental genomics to mammals.

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Sprache(n): eng - English
 Datum: 2021-08-10
 Publikationsstatus: Online veröffentlicht
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 Identifikatoren: DOI: 10.1101/2021.08.09.454869
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Titel: bioRxiv
Genre der Quelle: Webseite
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