Deutsch
 
Hilfe Datenschutzhinweis Impressum
  DetailsucheBrowse

Datensatz

DATENSATZ AKTIONENEXPORT
Zur Ablage hinzufügen
 Lokale TagsFreigabegeschichteDetailsÜbersicht
  Discovery of 42 genome-wide significant loci associated with dyslexia

Doust, C., Fontanillas, P., Eising, E., Gordon, S. D., Wang, Z., Alagöz, G., et al. (2022). Discovery of 42 genome-wide significant loci associated with dyslexia. Nature Genetics. doi:10.1038/s41588-022-01192-y.

Item is

 

einblenden: alle ausblenden: alle

Basisdaten

einblenden: ausblenden:
Datensatz-Permalink: https://hdl.handle.net/21.11116/0000-0009-1B5A-5 Versions-Permalink: https://hdl.handle.net/21.11116/0000-000D-07A8-E
Genre: Zeitschriftenartikel

Dateien

einblenden: Dateien
ausblenden: Dateien
:
s41588-022-01192-y.pdf (Verlagsversion), 8MB
Öffnen   Speichern
Datei-Permalink:
https://hdl.handle.net/21.11116/0000-000B-4D66-D
Name:
s41588-022-01192-y.pdf
Beschreibung:
-
OA-Status:
Hybrid
Sichtbarkeit:
Öffentlich
MIME-Typ / Prüfsumme:
application/pdf / [MD5]
Technische Metadaten:
Öffnen
Copyright Datum:
2022
Copyright Info:
This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit
Lizenz:
http://creativecommons.org/licenses/by/4.0/

Externe Referenzen

einblenden:

Urheber

einblenden:
ausblenden:
 Urheber:
Doust, Catherine1, Autor
Fontanillas, Pierre2, Autor
Eising, Else3, Autor           
Gordon, Scott D.4, Autor
Wang, Zhengjun5, Autor
Alagöz, Gökberk3, Autor           
Molz, Barbara3, Autor           
23andMe Research Team, Autor
Quantitative Trait Working Group of the GenLang Consortium, Autor
St Pourcain, Beate3, 6, Autor           
Francks, Clyde3, 7, Autor           
Marioni, Riccardo E.1, Autor
Zhao, Jingjing5, Autor
Paracchini, Silvia8, Autor
Talcott, Joel B.9, Autor
Monaco, Anthony P.10, Autor
Stein, John F.11, Autor
Gruen, Jeffrey R.12, Autor
Olson, Richard K.13, Autor
Willcutt, Erik G.13, Autor
DeFries, John C.13, AutorPennington, Bruce F.14, AutorSmith, Shelley D.15, AutorWright, Margaret J.16, AutorMartin, Nicholas G.4, AutorAuton, Adam2, AutorBates, Timothy C.1, AutorFisher, Simon E.3, 17, Autor           Luciano, Michelle1, Autor mehr..
Affiliations:
1University of Edinburgh, Edinburgh, UK, ou_persistent22              
223andMe, Inc., Sunnyvale, CA, USA, ou_persistent22              
3Language and Genetics Department, MPI for Psycholinguistics, Max Planck Society, ou_792549              
4QIMR Berghofer Medical Research Institute, Brisbane, Australia, ou_persistent22              
5Shaanxi Normal University, Xi'an, China, ou_persistent22              
6Population genetics of human communication, MPI for Psycholinguistics, Max Planck Society, ou_2579694              
7Imaging Genomics, MPI for Psycholinguistics, Max Planck Society, ou_2579692              
8University of St Andrews, St Andrews, UK, ou_persistent22              
9Aston Brain Centre, Birmingham, UK, ou_persistent22              
10Tufts University, Medford, Medford, MA, USA, ou_persistent22              
11Oxford University, Oxford, UK, ou_persistent22              
12Yale Medical School, New Haven, CT, USA, ou_persistent22              
13University of Colorado, Boulder, CO, USA, ou_persistent22              
14University of Denver, Denver, CO, USA, ou_persistent22              
15University of Nebraska Medical Center, Omaha, NE, USA, ou_persistent22              
16University of Queensland, Brisbane, Australia, ou_persistent22              
17Donders Institute for Brain, Cognition and Behaviour, External Organizations, ou_55236              

Inhalt

einblenden:
ausblenden:
Schlagwörter: -
 Zusammenfassung: Reading and writing are crucial life skills but roughly one in ten children are affected by dyslexia, which can persist into adulthood. Family studies of dyslexia suggest heritability up to 70%, yet few convincing genetic markers have been found. Here we performed a genome-wide association study of 51,800 adults self-reporting a dyslexia diagnosis and 1,087,070 controls and identified 42 independent genome-wide significant loci: 15 in genes linked to cognitive ability/educational attainment, and 27 new and potentially more specific to dyslexia. We validated 23 loci (13 new) in independent cohorts of Chinese and European ancestry. Genetic etiology of dyslexia was similar between sexes, and genetic covariance with many traits was found, including ambidexterity, but not neuroanatomical measures of language-related circuitry. Dyslexia polygenic scores explained up to 6% of variance in reading traits, and might in future contribute to earlier identification and remediation of dyslexia.

Details

einblenden:
ausblenden:
Sprache(n): eng - English
 Datum: 2022-10-20
 Publikationsstatus: Online veröffentlicht
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1038/s41588-022-01192-y
 Art des Abschluß: -

Veranstaltung

einblenden:

Entscheidung

einblenden:

Projektinformation

einblenden:

Quelle 1

einblenden:
ausblenden:
Titel: Nature Genetics
  Andere : Nature Genet.
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: New York, NY : Nature America, Inc.
Seiten: - Band / Heft: - Artikelnummer: - Start- / Endseite: - Identifikator: ISSN: 1061-4036
CoNE: https://pure.mpg.de/cone/journals/resource/954925598609