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  PERM1 interacts with the MICOS-MIB complex to connect the mitochondria and sarcolemma via ankyrin B

Bock, T., Turk, C., Aravamudhan, S., Keufgens, L., Bloch, W., Rozsivalova, D. H., et al. (2021). PERM1 interacts with the MICOS-MIB complex to connect the mitochondria and sarcolemma via ankyrin B. NATURE COMMUNICATIONS, 12(1): 4900. doi:10.1038/s41467-021-25185-3.

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 Creators:
Bock, Theresa, Author
Turk, Clara, Author
Aravamudhan, Sriram1, Author           
Keufgens, Lena, Author
Bloch, Wilhelm, Author
Rozsivalova, Dieu Hien, Author
Romanello, Vanina, Author
Nogara, Leonardo, Author
Blaauw, Bert, Author
Trifunovic, Aleksandra, Author
Braun, Thomas1, Author           
Krueger, Marcus1, Author           
Affiliations:
1Cardiac Development and Remodeling, Max Planck Institute for Heart and Lung Research, Max Planck Society, ou_2591695              

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Free keywords: STRUCTURAL ORGANIZATION; INTERMEDIATE-FILAMENTS; OXIDATIVE CAPACITY; CONTACT SITE; PROTEIN; BIOGENESIS; EXERCISE; METABOLISM; RESISTANCE; SOFTWAREScience & Technology - Other Topics;
 Abstract: Skeletal muscle subsarcolemmal mitochondria (SSM) and intermyofibrillar mitochondria subpopulations have distinct metabolic activity and sensitivity, though the mechanisms that localize SSM to peripheral areas of muscle fibers are poorly understood. A protein interaction study and complexome profiling identifies PERM1 interacts with the MICOS-MIB complex. Ablation of Perm1 in mice reduces muscle force, decreases mitochondrial membrane potential and complex I activity, and reduces the numbers of SSM in skeletal muscle. We demonstrate PERM1 interacts with the intracellular adaptor protein ankyrin B (ANKB) that connects the cytoskeleton to the plasma membrane. Moreover, we identify a C-terminal transmembrane helix that anchors PERM1 into the outer mitochondrial membrane. We conclude PERM1 functions in the MICOS-MIB complex and acts as an adapter to connect the mitochondria with the sarcolemma via ANKB. Mitochondria in skeletal muscle have distinct localization and properties through unclear mechanisms. Here, the authors use complexome profiling and immunoprecipitations to identify PERM1 as a MICOS-MIB complex interactor that also binds ankyrin B, suggesting PERM1 directs the mitochondria to the membrane.

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Language(s): eng - English
 Dates: 2021-08-12
 Publication Status: Published online
 Pages: 15
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: ISI: 000686181800009
DOI: 10.1038/s41467-021-25185-3
PMID: 34385433
 Degree: -

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Title: NATURE COMMUNICATIONS
Source Genre: Journal
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Publ. Info: HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY : NATURE PORTFOLIO
Pages: - Volume / Issue: 12 (1) Sequence Number: 4900 Start / End Page: - Identifier: ISSN: 2041-1723