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  Genome-wide association study in 8,956 German individuals identifies influence of ABO histo-blood groups on gut microbiome

Rühlemann, M. C., Hermes, B., Bang, C., Doms, S., Moitinho-Silva, L., Thingholm, L. B., et al. (2021). Genome-wide association study in 8,956 German individuals identifies influence of ABO histo-blood groups on gut microbiome. Nature Genetics, 53(2), 147-155. doi:10.1038/s41588-020-00747-1.

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 Creators:
Rühlemann, Malte Christoph, Author
Hermes, Britt1, Author              
Bang, Corinna, Author
Doms, Shauni1, Author              
Moitinho-Silva, Lucas, Author
Thingholm, Louise Bruun, Author
Frost, Fabian, Author
Degenhardt, Frauke, Author
Wittig, Michael, Author
Kässens, Jan, Author
Weiss, Frank Ulrich, Author
Peters, Annette, Author
Neuhaus, Klaus, Author
Völker, Uwe, Author
Völzke, Henry, Author
Homuth, Georg, Author
Weiss, Stefan, Author
Grallert, Harald, Author
Laudes, Matthias, Author
Lieb, Wolfgang, Author
Haller, Dirk, AuthorLerch, Markus M., AuthorBaines, John F.1, Author              Franke, Andre, Author more..
Affiliations:
1Guest Group Evolutionary Genomics, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445638              

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 Abstract: The intestinal microbiome is implicated as an important modulating factor in multiple inflammatory1,2, neurologic3 and neoplastic diseases4. Recent genome-wide association studies yielded inconsistent, underpowered and rarely replicated results such that the role of human host genetics as a contributing factor to microbiome assembly and structure remains uncertain5–11. Nevertheless, twin studies clearly suggest host genetics as a driver of microbiome composition11. In a genome-wide association analysis of 8,956 German individuals, we identified 38 genetic loci to be associated with single bacteria and overall microbiome composition. Further analyses confirm the identified associations of ABO histo-blood groups and FUT2 secretor status with Bacteroides and Faecalibacterium spp. Mendelian randomization analysis suggests causative and protective effects of gut microbes, with clade-specific effects on inflammatory bowel disease. This holistic investigative approach of the host, its genetics and its associated microbial communities as a ‘metaorganism’ broaden our understanding of disease etiology, and emphasize the potential for implementing microbiota in disease treatment and management.

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Language(s): eng - English
 Dates: 2020-01-142020-11-032021-01-182021-02
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1038/s41588-020-00747-1
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Title: Nature Genetics
  Other : Nature Genet.
Source Genre: Journal
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Publ. Info: New York, NY : Nature America, Inc.
Pages: - Volume / Issue: 53 (2) Sequence Number: - Start / End Page: 147 - 155 Identifier: ISSN: 1061-4036
CoNE: https://pure.mpg.de/cone/journals/resource/954925598609