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  Dynamical consequences of regional heterogeneity in the brain’s transcriptional landscape

Deco, G., Kringelbach, M. L., Arnatkeviciute, A., Oldham, S., Sabaroedin, K., Rogasch, N. C., et al. (2021). Dynamical consequences of regional heterogeneity in the brain’s transcriptional landscape. Science Advances, 7(29): eabf4752. doi:10.1126/sciadv.abf4752.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0009-246F-3 Version Permalink: https://hdl.handle.net/21.11116/0000-000D-4B8E-0
Genre: Journal Article

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 Creators:
Deco, Gustavo1, 2, 3, 4, Author           
Kringelbach, Morten L.5, 6, Author
Arnatkeviciute, Aurina4, Author
Oldham, Stuart4, Author
Sabaroedin, Kristina4, Author
Rogasch, Nigel C.4, 7, Author
Aquino, Kevin M.4, 8, Author
Fornito, Alex4, Author
Affiliations:
1Computational Neuroscience Group, Department of Information and Communication Technologies, Center for Brain and Cognition, University Pompeu Fabra, Barcelona, Spain, ou_persistent22              
2Catalan Institution for Research and Advanced Studies (ICREA), University Pompeu Fabra, Barcelona, Spain, ou_persistent22              
3Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634551              
4Turner Institute for Brain and Mental Health, Monash University, Melbourne, Australia, ou_persistent22              
5Department of Psychiatry, University of Oxford, United Kingdom, ou_persistent22              
6Department of Clinical Medicine, Center for Music in the Brain, Aarhus University, Denmark, ou_persistent22              
7Department of Psychiatry, Adelaide Medical School, University of Adelaide, Australia, ou_persistent22              
8School of Physics, University of Sydney, Australia, ou_persistent22              

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 Abstract: Brain regions vary in their molecular and cellular composition, but how this heterogeneity shapes neuronal dynamics is unclear. Here, we investigate the dynamical consequences of regional heterogeneity using a biophysical model of whole-brain functional magnetic resonance imaging (MRI) dynamics in humans. We show that models in which transcriptional variations in excitatory and inhibitory receptor (E:I) gene expression constrain regional heterogeneity more accurately reproduce the spatiotemporal structure of empirical functional connectivity estimates than do models constrained by global gene expression profiles or MRI-derived estimates of myeloarchitecture. We further show that regional transcriptional heterogeneity is essential for yielding both ignition-like dynamics, which are thought to support conscious processing, and a wide variance of regional-activity time scales, which supports a broad dynamical range. We thus identify a key role for E:I heterogeneity in generating complex neuronal dynamics and demonstrate the viability of using transcriptomic data to constrain models of large-scale brain function.

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Language(s): eng - English
 Dates: 2021-07-142021-07
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1126/sciadv.abf4752
PMID: 34261652
PMC: PMC8279501
 Degree: -

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Project name : -
Grant ID : PID2019-105772GB-I00 MCIU AEI; PCI2018-092891
Funding program : -
Funding organization : Spanish Ministry of Science, Innovation and Universities (MCIU)
Project name : -
Grant ID : 945539
Funding program : -
Funding organization : Human Brain Project (HBP)
Project name : -
Grant ID : 101017716; 2017 SGR 1545
Funding program : -
Funding organization : Catalan Agency for Management of University and Research Grants (AGAUR)
Project name : FET Proactive programme
Grant ID : 860563
Funding program : Horizon 2020
Funding organization : European Union
Project name : MSCA-ITN Innovative Training Networks
Grant ID : 001-P-001682
Funding program : Horizon 2020
Funding organization : European Union
Project name : Brain-Connects: Brain Connectivity during Stroke Recovery and Rehabilitation
Grant ID : 201725.33
Funding program : -
Funding organization : Fundacio La Marato TV3
Project name : -
Grant ID : DNRF117
Funding program : Center for Music in the Brain
Funding organization : Danish National Research Foundation (DNRF)
Project name : Centre for Eudaimonia and Human Flourishing
Grant ID : -
Funding program : -
Funding organization : Pettit and Carlsberg Foundations
Project name : -
Grant ID : -
Funding program : -
Funding organization : Sylvia and Charles Viertel Charitable Foundation
Project name : -
Grant ID : -
Funding program : -
Funding organization : National Health and Medical Research Council (NHMRC) of Australia

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Title: Science Advances
  Other : Sci. Adv.
Source Genre: Journal
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Publ. Info: Washington : AAAS
Pages: - Volume / Issue: 7 (29) Sequence Number: eabf4752 Start / End Page: - Identifier: ISSN: 2375-2548
CoNE: https://pure.mpg.de/cone/journals/resource/2375-2548