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  Dynamical consequences of regional heterogeneity in the brain’s transcriptional landscape

Deco, G., Kringelbach, M. L., Arnatkeviciute, A., Oldham, S., Sabaroedin, K., Rogasch, N. C., Aquino, K. M., & Fornito, A. (2021). Dynamical consequences of regional heterogeneity in the brain’s transcriptional landscape. Science Advances, 7(29):. doi:10.1126/sciadv.abf4752.

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アイテムのパーマリンク: https://hdl.handle.net/21.11116/0000-0009-246F-3 版のパーマリンク: https://hdl.handle.net/21.11116/0000-000D-4B8E-0
資料種別: 学術論文

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Deco_2021.pdf (出版社版), 3MB
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https://hdl.handle.net/21.11116/0000-0009-2471-F
ファイル名:
Deco_2021.pdf
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Gold
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公開
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application/pdf / [MD5]
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CCライセンス:
https://creativecommons.org/licenses/by-nc/4.0/

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作成者

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 作成者:
Deco, Gustavo1, 2, 3, 4, 著者           
Kringelbach, Morten L.5, 6, 著者
Arnatkeviciute, Aurina4, 著者
Oldham, Stuart4, 著者
Sabaroedin, Kristina4, 著者
Rogasch, Nigel C.4, 7, 著者
Aquino, Kevin M.4, 8, 著者
Fornito, Alex4, 著者
所属:
1Computational Neuroscience Group, Department of Information and Communication Technologies, Center for Brain and Cognition, University Pompeu Fabra, Barcelona, Spain, ou_persistent22              
2Catalan Institution for Research and Advanced Studies (ICREA), University Pompeu Fabra, Barcelona, Spain, ou_persistent22              
3Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634551              
4Turner Institute for Brain and Mental Health, Monash University, Melbourne, Australia, ou_persistent22              
5Department of Psychiatry, University of Oxford, United Kingdom, ou_persistent22              
6Department of Clinical Medicine, Center for Music in the Brain, Aarhus University, Denmark, ou_persistent22              
7Department of Psychiatry, Adelaide Medical School, University of Adelaide, Australia, ou_persistent22              
8School of Physics, University of Sydney, Australia, ou_persistent22              

内容説明

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 要旨: Brain regions vary in their molecular and cellular composition, but how this heterogeneity shapes neuronal dynamics is unclear. Here, we investigate the dynamical consequences of regional heterogeneity using a biophysical model of whole-brain functional magnetic resonance imaging (MRI) dynamics in humans. We show that models in which transcriptional variations in excitatory and inhibitory receptor (E:I) gene expression constrain regional heterogeneity more accurately reproduce the spatiotemporal structure of empirical functional connectivity estimates than do models constrained by global gene expression profiles or MRI-derived estimates of myeloarchitecture. We further show that regional transcriptional heterogeneity is essential for yielding both ignition-like dynamics, which are thought to support conscious processing, and a wide variance of regional-activity time scales, which supports a broad dynamical range. We thus identify a key role for E:I heterogeneity in generating complex neuronal dynamics and demonstrate the viability of using transcriptomic data to constrain models of large-scale brain function.

資料詳細

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言語: eng - English
 日付: 2021-07-142021-07
 出版の状態: 出版
 ページ: -
 出版情報: -
 目次: -
 査読: -
 識別子（DOI, ISBNなど）: DOI: 10.1126/sciadv.abf4752
PMID: 34261652
PMC: PMC8279501
 学位: -

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Project information

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Project name : -
Grant ID : PID2019-105772GB-I00 MCIU AEI; PCI2018-092891
Funding program : -
Funding organization : Spanish Ministry of Science, Innovation and Universities (MCIU)
Project name : -
Grant ID : 945539
Funding program : -
Funding organization : Human Brain Project (HBP)
Project name : -
Grant ID : 101017716; 2017 SGR 1545
Funding program : -
Funding organization : Catalan Agency for Management of University and Research Grants (AGAUR)
Project name : FET Proactive programme
Grant ID : 860563
Funding program : Horizon 2020
Funding organization : European Union
Project name : MSCA-ITN Innovative Training Networks
Grant ID : 001-P-001682
Funding program : Horizon 2020
Funding organization : European Union
Project name : Brain-Connects: Brain Connectivity during Stroke Recovery and Rehabilitation
Grant ID : 201725.33
Funding program : -
Funding organization : Fundacio La Marato TV3
Project name : -
Grant ID : DNRF117
Funding program : Center for Music in the Brain
Funding organization : Danish National Research Foundation (DNRF)
Project name : Centre for Eudaimonia and Human Flourishing
Grant ID : -
Funding program : -
Funding organization : Pettit and Carlsberg Foundations
Project name : -
Grant ID : -
Funding program : -
Funding organization : Sylvia and Charles Viertel Charitable Foundation
Project name : -
Grant ID : -
Funding program : -
Funding organization : National Health and Medical Research Council (NHMRC) of Australia

出版物 1

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出版物名: Science Advances
  その他 : Sci. Adv.
種別: 学術雑誌
 著者・編者:
所属:
出版社, 出版地: Washington : AAAS
ページ: - 巻号: 7 (29) 通巻号: eabf4752 開始・終了ページ: - 識別子（ISBN, ISSN, DOIなど）: ISSN: 2375-2548
CoNE: https://pure.mpg.de/cone/journals/resource/2375-2548