English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse
  1. Item Summary / 
  2. View item

Item

ITEM ACTIONSEXPORT
 
 
DownloadE-Mail
 DetailsSummary
  The influence of radio-frequency transmit field inhomogeneities on the accuracy of g-ratio weighted imaging

Emmenegger, T. M., David, G., Ashtarayeh, M., Fritz, F. J., Ellerbrock, I., Helms, G., et al. (2021). The influence of radio-frequency transmit field inhomogeneities on the accuracy of g-ratio weighted imaging. Frontiers in Neuroscience, 15: 674719. doi:10.3389/fnins.2021.674719.

Item is

 

show all hide all

Basic

show hide
Item Permalink: https://hdl.handle.net/21.11116/0000-0009-24A2-7 Version Permalink: https://hdl.handle.net/21.11116/0000-000B-2A68-2
Genre: Journal Article

Files

show Files
hide Files
:
Emmenegger_2021.pdf (Publisher version), 7MB
View   Save
File Permalink:
https://hdl.handle.net/21.11116/0000-0009-24A4-5
Name:
Emmenegger_2021.pdf
Description:
-
OA-Status:
Gold
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
View
Copyright Date:
-
Copyright Info:
-
License:
https://creativecommons.org/licenses/by/4.0/

Locators

show

Creators

show
hide
 Creators:
Emmenegger, Tim M.1, 2, Author
David, Gergely1, Author
Ashtarayeh, Mohammad2, Author
Fritz, Francisco J.2, Author
Ellerbrock, Isabel3, Author
Helms, Gunther4, Author
Balteau, Evelyne5, Author
Freund, Patrick1, 6, 7, Author           
Mohammadi, Siawoosh2, 6, Author           
Affiliations:
1Balgrist Spinal Cord Injury Center, Balgrist University Hospital, Zurich, Switzerland, ou_persistent22              
2Department of Systems Neuroscience, University Medical Center Hamburg-Eppendorf, Germany, ou_persistent22              
3Department of Clinical Neuroscience, Stockholm Brain Institute, Karolinska Institute, Stockholm, Sweden, ou_persistent22              
4Department of Medical Radiation Physics, Skånes University Hospital, Stockholm, Sweden, ou_persistent22              
5GIGA Institute, University of Liège, Belgium, ou_persistent22              
6Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2205649              
7Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, United Kingdom, ou_persistent22              

Content

show
hide
Free keywords: Myelin volume fraction; Axon volume fraction; Radio-frequency transmit field inhomogeneities; B1+ correction; Multi-parameter mapping; Diffusion MRI; Magnetization transfer saturation; MR g-ratio
 Abstract: G-ratio weighted imaging is a non-invasive, in-vivo MRI-based technique that aims at estimating an aggregated measure of relative myelination of axons across the entire brain white matter. The MR g-ratio and its constituents (axonal and myelin volume fraction) are more specific to the tissue microstructure than conventional MRI metrics targeting either the myelin or axonal compartment. To calculate the MR g-ratio, an MRI-based myelin-mapping technique is combined with an axon-sensitive MR technique (such as diffusion MRI). Correction for radio-frequency transmit (B1+) field inhomogeneities is crucial for myelin mapping techniques such as magnetization transfer saturation. Here we assessed the effect of B1+ correction on g-ratio weighted imaging. To this end, the B1+ field was measured and the B1+ corrected MR g-ratio was used as the reference in a Bland-Altman analysis. We found a substantial bias (≈-89%) and error (≈37%) relative to the dynamic range of g-ratio values in the white matter if the B1+ correction was not applied. Moreover, we tested the efficiency of a data-driven B1+ correction approach that was applied retrospectively without additional reference measurements. We found that it reduced the bias and error in the MR g-ratio by a factor of three. The data-driven correction is readily available in the open-source hMRI toolbox (www.hmri.info) which is embedded in the statistical parameter mapping (SPM) framework.

Details

show
hide
Language(s): eng - English
 Dates: 2021-03-012021-06-012021-07-05
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.3389/fnins.2021.674719
Other: eCollection 2021
PMID: 34290579
PMC: PMC8287210
 Degree: -

Event

show

Legal Case

show

Project information

show hide
Project name : -
Grant ID : 01EW1711A and B
Funding program : -
Funding organization : Federal Ministry of Education and Research
Project name : -
Grant ID : AL 1156/2-1;GE 2967/1-1; MO 2397/5-1; MO 2249/3–1; MO 2397/4-1
Funding program : -
Funding organization : German Research Foundation
Project name : -
Grant ID : NT 2014-6193
Funding program : -
Funding organization : Swedish Research Council
Project name : -
Grant ID : PCEFP3_181362/1
Funding program : -
Funding organization : SNF Eccellenza Professorial Fellowship
Project name : -
Grant ID : 634541
Funding program : Horizon 2020
Funding organization : European Union

Source 1

show
hide
Title: Frontiers in Neuroscience
  Other : Front Neurosci
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Lausanne, Switzerland : Frontiers Research Foundation
Pages: - Volume / Issue: 15 Sequence Number: 674719 Start / End Page: - Identifier: ISSN: 1662-4548
ISSN: 1662-453X
CoNE: https://pure.mpg.de/cone/journals/resource/1662-4548