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  Semi- and fully synthetic carbohydrate vaccines against pathogenic bacteria : recent developments

Zasłona, M. E., Downey, M., Seeberger, P. H., & Moscovitz, O. (2021). Semi- and fully synthetic carbohydrate vaccines against pathogenic bacteria: recent developments. Biochemical Society Transactions, 49(5), 2411-2429. doi:10.1042/BST20210766.

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 Creators:
Zasłona, Magdalena E.1, Author           
Downey, Michael2, Author           
Seeberger, Peter H.2, Author           
Moscovitz, Oren1, Author           
Affiliations:
1Oren Moscovitz, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_3176803              
2Peter H. Seeberger - Vaccine Development, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863308              

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Free keywords: antibacterial vaccines, bacteria, capsular polysaccharides, carbohydrates, synthetic carbohydrate, vaccines
 Abstract: The importance of vaccine-induced protection was repeatedly demonstrated over the last three decades and emphasized during the recent COVID-19 pandemic as the safest and most effective way of preventing infectious diseases. Vaccines have controlled, and in some cases, eradicated global viral and bacterial infections with high efficiency and at a relatively low cost. Carbohydrates form the capsular sugar coat that surrounds the outer surface of human pathogenic bacteria. Specific surface-exposed bacterial carbohydrates serve as potent vaccine targets that broadened our toolbox against bacterial infections. Since first approved for commercial use, antibacterial carbohydrate-based vaccines mostly rely on inherently complex and heterogenous naturally derived polysaccharides, challenging to obtain in a pure, safe, and cost-effective manner. The introduction of synthetic fragments identical with bacterial capsular polysaccharides provided well-defined and homogenous structures that resolved many challenges of purified polysaccharides. The success of semisynthetic glycoconjugate vaccines against bacterial infections, now in different phases of clinical trials, opened up new possibilities and encouraged further development towards fully synthetic antibacterial vaccine solutions. In this mini-review, we describe the recent achievements in semi- and fully synthetic carbohydrate vaccines against a range of human pathogenic bacteria, focusing on preclinical and clinical studies.

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Language(s): eng - English
 Dates: 2021-09-082021
 Publication Status: Published in print
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 Rev. Type: -
 Identifiers: DOI: 10.1042/BST20210766
BibTex Citekey: 10.1042/BST20210766
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Title: Biochemical Society Transactions
Source Genre: Journal
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Publ. Info: London : Portland Press.
Pages: - Volume / Issue: 49 (5) Sequence Number: - Start / End Page: 2411 - 2429 Identifier: ISSN: 0300-5127