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  Circuit mechanisms for the chemical modulation of cortex-wide network interactions and behavioral variability

Pfeffer, T., Ponce-Alvarez, A., Tsetsos, K., Meindertsma, T., Gahnström, C. J., van den Brink, R. L., et al. (2021). Circuit mechanisms for the chemical modulation of cortex-wide network interactions and behavioral variability. Science Advances, 7(29): eabf5620. doi:10.1126/sciadv.abf5620.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0009-2646-E Version Permalink: https://hdl.handle.net/21.11116/0000-000D-4BBF-9
Genre: Journal Article

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 Creators:
Pfeffer, Thomas1, 2, Author
Ponce-Alvarez, Adrian2, Author
Tsetsos, Konstantinos1, Author
Meindertsma, Thomas1, 3, Author
Gahnström, Christoffer Julius1, Author
van den Brink, Ruud Lucas1, Author
Nolte, Guido1, Author
Engel, Andreas Karl1, Author
Deco, Gustavo2, 4, 5, 6, Author           
Donner, Tobias Hinrich1, 3, 7, 8, Author
Affiliations:
1Department of Neurophysiology and Pathophysiology, University Medical Center Hamburg-Eppendorf, Germany, ou_persistent22              
2Center for Brain and Cognition, University Pompeu Fabra, Barcelona, Spain, ou_persistent22              
3Department of Psychology, University of Amsterdam, the Netherlands, ou_persistent22              
4Catalan Institution for Research and Advanced Studies (ICREA), University Pompeu Fabra, Barcelona, Spain, ou_persistent22              
5Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634551              
6School of Psychological Sciences, Monash University, Melbourne, Australia, ou_persistent22              
7Amsterdam Brain and Cognition (ABC), University of Amsterdam, the Netherlands, ou_persistent22              
8Bernstein Center for Computational Neuroscience, Berlin, Germany, ou_persistent22              

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 Abstract: Influential theories postulate distinct roles of catecholamines and acetylcholine in cognition and behavior. However, previous physiological work reported similar effects of these neuromodulators on the response properties (specifically, the gain) of individual cortical neurons. Here, we show a double dissociation between the effects of catecholamines and acetylcholine at the level of large-scale interactions between cortical areas in humans. A pharmacological boost of catecholamine levels increased cortex-wide interactions during a visual task, but not rest. An acetylcholine boost decreased interactions during rest, but not task. Cortical circuit modeling explained this dissociation by differential changes in two circuit properties: the local excitation-inhibition balance (more strongly increased by catecholamines) and intracortical transmission (more strongly reduced by acetylcholine). The inferred catecholaminergic mechanism also predicted noisier decision-making, which we confirmed for both perceptual and value-based choice behavior. Our work highlights specific circuit mechanisms for shaping cortical network interactions and behavioral variability by key neuromodulatory systems.

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Language(s): eng - English
 Dates: 2021-07-162021
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1126/sciadv.abf5620
PMID: 34272245
PMC: PMC8284895
 Degree: -

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Project name : -
Grant ID : 161A130
Funding program : -
Funding organization : Bundesministerium für Bildung und Forschung (BMBF)
Project name : -
Grant ID : 2017 SGR 1545
Funding program : -
Funding organization : Catalan Agencia de Gestión
Project name : -
Grant ID : DO1230/1; DO1240/1; SFB936/A3; SFB936/A7; SFB936/Z3; TRR169/B4/C1
Funding program : -
Funding organization : Deutsche Forschungsgemeinschaft (DFG)
Project name : -
Grant ID : 720270; 785907; 802905
Funding program : Horizon 2020
Funding organization : European Union
Project name : -
Grant ID : 406-14-016
Funding program : -
Funding organization : Netherlands Organization for Scientific Research (NWO)
Project name : -
Grant ID : -
Funding program : -
Funding organization : Alexander-von-Humboldt Foundation
Project name : -
Grant ID : -
Funding program : -
Funding organization : International Brain Research Organization

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Title: Science Advances
  Other : Sci. Adv.
Source Genre: Journal
 Creator(s):
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Publ. Info: Washington : AAAS
Pages: - Volume / Issue: 7 (29) Sequence Number: eabf5620 Start / End Page: - Identifier: ISSN: 2375-2548
CoNE: https://pure.mpg.de/cone/journals/resource/2375-2548