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  Decreased thalamo-cortico connectivity during an implicit sequence motor learning task and 7 days escitalopram intake

Molloy, E., Zsido, R., Piecha, F. A., Beinhölzl, N., Scharrer, U., Zheleva, G., et al. (2021). Decreased thalamo-cortico connectivity during an implicit sequence motor learning task and 7 days escitalopram intake. Scientific Reports, 11(1): 15060. doi:10.1038/s41598-021-94009-7.

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 Creators:
Molloy, Eoin1, 2, 3, Author              
Zsido, Rachel1, 2, 3, 4, Author              
Piecha, Fabian A.1, 2, Author
Beinhölzl, Nathalie1, 2, Author              
Scharrer, Ulrike1, 2, Author
Zheleva, Gergana1, 2, Author
Regenthal, Ralf5, Author
Sehm, Bernhard2, 6, Author              
Nikulin, Vadim V.2, 7, Author              
Möller, Harald E.8, Author              
Villringer, Arno2, 3, 9, 10, Author              
Sacher, Julia1, 2, 3, 4, 10, Author              
Mueller, Karsten8, Author              
Affiliations:
1Minerva Research Group EGG (Emotion & neuroimaGinG) Lab, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_3230775              
2Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
3International Max Planck Research School on Neuroscience of Communication: Function, Structure, and Plasticity, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_2616696              
4Max Planck School of Cognition, Leipzig, Germany, ou_persistent22              
5Division of Clinical Pharmacology, Rudolf-Boehm-Institute of Pharmacology and Toxicology, University of Leipzig, Germany, ou_persistent22              
6Department of Neurology, Martin Luther University Halle-Wittenberg, Germany, ou_persistent22              
7Centre for Cognition and Decision Making, National Research University Higher School of Economics, Moscow, Russia, ou_persistent22              
8Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634558              
9MindBrainBody Institute, Berlin School of Mind and Brain, Humboldt University Berlin, Germany, ou_persistent22              
10Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              

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Free keywords: Learning and memory; Motor control; Neurochemistry; Neuroscience; Pharmacology
 Abstract: Evidence suggests that selective serotonin reuptake inhibitors (SSRIs) reorganize neural networks via a transient window of neuroplasticity. While previous findings support an effect of SSRIs on intrinsic functional connectivity, little is known regarding the influence of SSRI-administration on connectivity during sequence motor learning. To investigate this, we administered 20 mg escitalopram or placebo for 1-week to 60 healthy female participants undergoing concurrent functional magnetic resonance imaging and sequence motor training in a double-blind randomized controlled design. We assessed task-modulated functional connectivity with a psycho-physiological interaction (PPI) analysis in the thalamus, putamen, cerebellum, dorsal premotor, primary motor, supplementary motor, and dorsolateral prefrontal cortices. Comparing an implicit sequence learning condition to a control learning condition, we observed decreased connectivity between the thalamus and bilateral motor regions after 7 days of escitalopram intake. Additionally, we observed a negative correlation between plasma escitalopram levels and PPI connectivity changes, with higher escitalopram levels being associated with greater thalamo-cortico decreases. Our results suggest that escitalopram enhances network-level processing efficiency during sequence motor learning, despite no changes in behaviour. Future studies in more diverse samples, however, with quantitative imaging of neurochemical markers of excitation and inhibition, are necessary to further assess neural responses to escitalopram.

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Language(s): eng - English
 Dates: 2021-01-082021-07-052021-07-23
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1038/s41598-021-94009-7
PMID: 34301974
PMC: PMC8302647
 Degree: -

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Title: Scientific Reports
  Abbreviation : Sci. Rep.
Source Genre: Journal
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Publ. Info: London, UK : Nature Publishing Group
Pages: - Volume / Issue: 11 (1) Sequence Number: 15060 Start / End Page: - Identifier: ISSN: 2045-2322
CoNE: https://pure.mpg.de/cone/journals/resource/2045-2322