English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Role of extracellular matrix structural components and tissue mechanics in the development of postoperative pancreatic fistula

Schmuck, R. B., Lippens, E., Wulsten, D., Garske, D., Strönisch, A., Pratschke, J., et al. (2021). Role of extracellular matrix structural components and tissue mechanics in the development of postoperative pancreatic fistula. Journal of Biomechanics, 128: 110714. doi:10.1016/j.jbiomech.2021.110714.

Item is

Basic

show hide
Genre: Journal Article

Files

show Files
hide Files
:
Article.pdf (Publisher version), 6MB
 
File Permalink:
-
Name:
Article.pdf
Description:
-
Visibility:
Restricted (Max Planck Institute of Colloids and Interfaces, MTKG; )
MIME-Type / Checksum:
application/pdf
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show
hide
Locator:
Article (Any fulltext)
Description:
-

Creators

show
hide
 Creators:
Schmuck, Rosa B., Author
Lippens, Evi, Author
Wulsten, Dag, Author
Garske, Daniela1, Author              
Strönisch, Annika, Author
Pratschke, Johann, Author
Sauer, Igor M., Author
Duda, Georg N., Author
Bahra, Marcus, Author
Cipitria, Amaia1, Author              
Affiliations:
1Amaia Cipitria, Biomaterialien, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_2489692              

Content

show
hide
Free keywords: Pancreatic ductal adenocarcinoma (PDAC), Postoperative pancreatic fistula (POPF), Extracellular matrix (ECM), Tissue mechanics
 Abstract: Radical resection remains the only curative treatment option in pancreatic cancer. Postoperative pancreatic fistulas (POPF) occur in up to 30 of patients leading to prolonged hospital-stay, increased cost of care and morbidity and mortality. Mechanical properties of the pancreas are associated with POPF. The aim of this study is to analyze the role of extracellular matrix (ECM) and tissue mechanics in the risk of POPF. Biopsies of 41 patients receiving a partial pancreas-resection are analyzed. Clinical data, ECM components and mechanical properties are correlated with POPF. Preoperative cholestasis is correlated with reduced risk of POPF, which comes along with a dilatation of the pancreatic duct and significantly higher content of collagen I. Patients developing POPF exhibited a degenerated tissue integrity, with significantly lower content of fibronectin and a trend for lower collagen I, III, IV and hyaluronic acid. This correlated with a soft tactile sensation of the surgeon during the intervention. However, this was not reflected with tissue mechanics evaluated by ex vivo uniaxial compression testing, where a significantly higher elastic modulus and no effect on the stress relaxation time were found. In conclusion, patients with cholestasis seem to have a lower risk for POPF, and an increase in collagen I. A degenerated matrix with lower content of structural ECM components correlates with increased risk of POPF. However, ex vivo uniaxial compression testing failed to clearly explain the link of ECM properties and POPF.

Details

show
hide
Language(s): eng - English
 Dates: 2021-08-272021
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1016/j.jbiomech.2021.110714
BibTex Citekey: SCHMUCK2021110714
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Journal of Biomechanics
  Other : J. Biomech.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: New York : Elsevier
Pages: - Volume / Issue: 128 Sequence Number: 110714 Start / End Page: - Identifier: ISSN: 0021-9290