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  Metabolic profiling of maternal serum of women a high-risk of spontaneous preterm birth using NMR and MGWAS approach

Gupta, J. K., Care, A., Goodfellow, L., Alfirevic, Z., Lian, L.-Y., Mueller-Myhsok, B., et al. (2021). Metabolic profiling of maternal serum of women a high-risk of spontaneous preterm birth using NMR and MGWAS approach. BIOSCIENCE REPORTS, 41(9): BSR20210759. doi:10.1042/BSR20210759.

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Gupta, Juhi K., Autor
Care, Angharad, Autor
Goodfellow, Laura, Autor
Alfirevic, Zarko, Autor
Lian, Lu-Yun, Autor
Mueller-Myhsok, Bertram1, Autor           
Alfirevic, Ana, Autor
Phelan, Marie M., Autor
Affiliations:
1RG Statistical Genetics, Max Planck Institute of Psychiatry, Max Planck Society, ou_2040288              

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 Zusammenfassung: Preterm birth (PTB) is a leading global cause of infant mortality. Risk factors include genetics, lifestyle choices and infection. Understanding the mechanism of PTB could aid the development of novel approaches to prevent PTB. This study aimed to investigate the metabolic biomarkers of PTB in early pregnancy and the association of significant metabolites with participant genotypes. Maternal sera collected at 16 and 20 weeks of gestation, from women who previously experienced PTB (high-risk) and women who did not (low-risk controls), were analysed using H-1 nuclear magnetic resonance (NMR) metabolomics and genome-wide screening microarray. ANOVA and probabilistic neural network (PNN) modelling were performed on the spectral bins. Metabolomics genome-wide association (MGWAS) of the spectral bins and genotype data from the same participants was applied to determine potential metabolite-gene pathways. Phenylalanine, acetate and lactate metabolite differences between PTB cases and controls were obtained by ANOVA and PNN showed strong prediction at week 20 (AUC = 0.89). MGWAS identified several metabolite bins with strong genetic associations. Cis-eQTL analysis highlighted TRAF1 (involved in the inflammatory pathway) local to a non-coding SNP associated with lactate at week 20 of gestation. MGWAS of a well-defined cohort of participants highlighted a lactate-TRAF1 relationship that could potentially contribute to PTB.

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 Datum: 2021
 Publikationsstatus: Online veröffentlicht
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 Identifikatoren: ISI: 000691773700001
DOI: 10.1042/BSR20210759
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Titel: BIOSCIENCE REPORTS
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: 41 (9) Artikelnummer: BSR20210759 Start- / Endseite: - Identifikator: ISSN: 0144-8463