English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  A transient postnatal quiescent period precedes emergence of mature cortical dynamics

Dominguez, S., Ma, L., Yu, H., Pouchelon, G., Mayer, C., Spyropoulos, G. D., et al. (2021). A transient postnatal quiescent period precedes emergence of mature cortical dynamics. eLife, 10: e69011. doi:10.7554/eLife.69011.

Item is

Basic

show hide
Genre: Journal Article

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Dominguez, Soledad, Author
Ma, Liang, Author
Yu, Han, Author
Pouchelon, Gabrielle, Author
Mayer, Christian1, Author           
Spyropoulos, George D., Author
Cea, Claudia, Author
Buzsaki, Gyorgy, Author
Fishell, Gord, Author
Khodagholy, Dion, Author
Gelinas, Jennifer N., Author
Affiliations:
1Research Group: Neurogenomics / Mayer, MPI of Neurobiology, Max Planck Society, ou_3060203              

Content

show
hide
Free keywords: EARLY MOTOR-ACTIVITY; SPINDLE BURSTS; VISUAL-CORTEX; ELECTRICAL-ACTIVITY; NEURONAL-ACTIVITY; HZ OSCILLATION; PLACE CELLS; PATTERNS; GAMMA; SLEEPLife Sciences & Biomedicine - Other Topics;
 Abstract: Mature neural networks synchronize and integrate spatiotemporal activity patterns to support cognition. Emergence of these activity patterns and functions is believed to be developmentally regulated, but the postnatal time course for neural networks to perform complex computations remains unknown. We investigate the progression of large-scale synaptic and cellular activity patterns across development using high spatiotemporal resolution in vivo electrophysiology in immature mice. We reveal that mature cortical processes emerge rapidly and simultaneously after a discrete but volatile transition period at the beginning of the second postnatal week of rodent development. The transition is characterized by relative neural quiescence, after which spatially distributed, temporally precise, and internally organized activity occurs. We demonstrate a similar developmental trajectory in humans, suggesting an evolutionarily conserved mechanism that could facilitate a transition in network operation. We hypothesize that this transient quiescent period is a requisite for the subsequent emergence of coordinated cortical networks.

Details

show
hide
Language(s): eng - English
 Dates: 2021-07-23
 Publication Status: Published in print
 Pages: 26
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: ISI: 000685207200001
DOI: 10.7554/eLife.69011
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: eLife
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Cambridge : eLife Sciences Publications
Pages: - Volume / Issue: 10 Sequence Number: e69011 Start / End Page: - Identifier: ISSN: 2050-084X
CoNE: https://pure.mpg.de/cone/journals/resource/2050-084X