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  Mass Spectrometry-Based Techniques to Elucidate the Sugar Code

Grabarics, M., Lettow, M., Kirschbaum, C., Greis, K., Manz, C., & Pagel, K. (2021). Mass Spectrometry-Based Techniques to Elucidate the Sugar Code. Chemical Reviews. doi:10.1021/acs.chemrev.1c00380.

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 Creators:
Grabarics, Márkó1, 2, Author              
Lettow, Maike1, 2, Author              
Kirschbaum, Carla1, 2, Author              
Greis, Kim1, 2, Author              
Manz, Christian1, 2, Author              
Pagel, Kevin1, 2, Author              
Affiliations:
1Molecular Physics, Fritz Haber Institute, Max Planck Society, ou_634545              
2Institute of Chemistry and Biochemistry, Freie Universität Berlin, Arnimallee 22, 14195 Berlin, Germany, ou_persistent22              

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 Abstract: Cells encode information in the sequence of biopolymers, such as nucleic acids, proteins, and glycans. Although glycans are essential to all living organisms, surprisingly little is known about the “sugar code” and the biological roles of these molecules. The reason glycobiology lags behind its counterparts dealing with nucleic acids and proteins lies in the complexity of carbohydrate structures, which renders their analysis extremely challenging. Building blocks that may differ only in the configuration of a single stereocenter, combined with the vast possibilities to connect monosaccharide units, lead to an immense variety of isomers, which poses a formidable challenge to conventional mass spectrometry. In recent years, however, a combination of innovative ion activation methods, commercialization of ion mobility–mass spectrometry, progress in gas-phase ion spectroscopy, and advances in computational chemistry have led to a revolution in mass spectrometry-based glycan analysis. The present review focuses on the above techniques that expanded the traditional glycomics toolkit and provided spectacular insight into the structure of these fascinating biomolecules. To emphasize the specific challenges associated with them, major classes of mammalian glycans are discussed in separate sections. By doing so, we aim to put the spotlight on the most important element of glycobiology: the glycans themselves.

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Language(s): eng - English
 Dates: 2021-05-032021-09-07
 Publication Status: Published online
 Pages: 69
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1021/acs.chemrev.1c00380
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Project name : GlycoSpec - Unravelling Glycochemistry with Ion Mobility Spectrometry and Gas-Phase Spectroscopy
Grant ID : 863934
Funding program : H2020
Funding organization : -

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Title: Chemical Reviews
  Other : Chem. Rev.
Source Genre: Journal
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Publ. Info: Washington, DC. : American Chemical Society
Pages: 69 Volume / Issue: - Sequence Number: - Start / End Page: - Identifier: ISSN: 0009-2665
CoNE: https://pure.mpg.de/cone/journals/resource/954925389243