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  Modeling host-associating microbes under selection

Bansept, F., Obeng, N., Schulenburg, H., & Traulsen, A. (2021). Modeling host-associating microbes under selection. The ISME Journal. doi:10.1038/s41396-021-01039-0.

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 Creators:
Bansept, Florence1, Author              
Obeng, Nancy, Author
Schulenburg, Hinrich2, Author              
Traulsen, Arne1, Author              
Affiliations:
1Department Evolutionary Theory, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445641              
2Max Planck Fellow Group Antibiotic Resistance Evolution, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_2600692              

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Free keywords: evolution; microbial ecology; microbiome; symbiosis; theoretical ecology
 Abstract: The concept of fitness is often reduced to a single component, such as the replication rate in a given habitat. For species with multi-step life cycles, this can be an unjustified oversimplification, as every step of the life cycle can contribute to the overall reproductive success in a specific way. In particular, this applies to microbes that spend part of their life cycles associated to a host. In this case, there is a selection pressure not only on the replication rates, but also on the phenotypic traits associated to migrating from the external environment to the host and vice-versa (i.e., the migration rates). Here, we investigate a simple model of a microbial lineage living, replicating, migrating and competing in and between two compartments: a host and an environment. We perform a sensitivity analysis on the overall growth rate to determine the selection gradient experienced by the microbial lineage. We focus on the direction of selection at each point of the phenotypic space, defining an optimal way for the microbial lineage to increase its fitness. We show that microbes can adapt to the two-compartment life cycle through either changes in replication or migration rates, depending on the initial values of the traits, the initial distribution across the two compartments, the intensity of competition, and the time scales involved in the life cycle versus the time scale of adaptation (which determines the adequate probing time to measure fitness). Overall, our model provides a conceptual framework to study the selection on microbes experiencing a host-associated life cycle.

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Language(s): eng - English
 Dates: 2021-05-282021-01-222021-06-092021-06-222021
 Publication Status: Published in print
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 Identifiers: DOI: 10.1038/s41396-021-01039-0
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Title: The ISME Journal
  Other : The ISME journal : multidisciplinary journal of microbial ecology
Source Genre: Journal
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Publ. Info: Basingstoke : Nature Publishing Group
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: - Identifier: ISSN: 1751-7370
CoNE: https://pure.mpg.de/cone/journals/resource/1751-7370