Functional harmonics reveal multi-dimensional basis functions underlying 
cortical organization

Glomb, Katharina; Kringelbach, Morten L.; Deco, Gustavo; Hagmann, Patric; Pearson, Joel; Atasoy, Selen

doi:10.1016/j.celrep.2021.109554

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Functional harmonics reveal multi-dimensional basis functions underlying cortical organization

Glomb, K., Kringelbach, M. L., Deco, G., Hagmann, P., Pearson, J., & Atasoy, S. (2021). Functional harmonics reveal multi-dimensional basis functions underlying cortical organization. Cell Reports, 36(8): 109554. doi:10.1016/j.celrep.2021.109554.

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Datensatz-Permalink: https://hdl.handle.net/21.11116/0000-0009-3E30-C Versions-Permalink: https://hdl.handle.net/21.11116/0000-000D-4BCE-8

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Urheber:
Glomb, Katharina¹, Autor
Kringelbach, Morten L.^{2, 3}, Autor
Deco, Gustavo^{4, 5, 6, 7}, Autor
Hagmann, Patric¹, Autor
Pearson, Joel⁸, Autor
Atasoy, Selen^{2, 3}, Autor

Affiliations:
1Department of Radiology, Centre hospitalier universitaire vaudois, Lausanne, Switzerland, ou_persistent22
2Department of Psychiatry, Warneford Hospital, University of Oxford, United Kingdom, ou_persistent22
3Department of Clinical Medicine, Center for Music in the Brain, Aarhus University, Denmark, ou_persistent22
4Center for Brain and Cognition, University Pompeu Fabra, Barcelona, Spain, ou_persistent22
5Catalan Institution for Research and Advanced Studies (ICREA), University Pompeu Fabra, Barcelona, Spain, ou_persistent22
6Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634551
7School of Psychological Sciences, Monash University, Melbourne, Australia, ou_persistent22
8School of Psychology, University of New South Wales, Sydney, Australia, ou_persistent22

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Schlagwörter: Human cortex; Functional connectivity; fMRI; Harmonic modes; Brain networks

Zusammenfassung: The human brain consists of specialized areas that flexibly interact to form a multitude of functional networks. Complementary to this notion of modular organization, brain function has been shown to vary along a smooth continuum across the whole cortex. We demonstrate a mathematical framework that accounts for both of these perspectives: harmonic modes. We calculate the harmonic modes of the brain’s functional connectivity graph, called “functional harmonics,” revealing a multi-dimensional, frequency-ordered set of basis functions. Functional harmonics link characteristics of cortical organization across several spatial scales, capturing aspects of intra-areal organizational features (retinotopy, somatotopy), delineating brain areas, and explaining macroscopic functional networks as well as global cortical gradients. Furthermore, we show how the activity patterns elicited by seven different tasks are reconstructed from a very small subset of functional harmonics. Our results suggest that the principle of harmonicity, ubiquitous in nature, also underlies functional cortical organization in the human brain.

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Sprache(n): eng - English

Datum: Geändert: 2021-04-06Eingereicht: 2020-10-29Angenommen: 2021-07-27Online veröffentlicht: 2021-08-24Erschienen: 2021-08-24

Publikationsstatus: Erschienen

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Identifikatoren: DOI: 10.1016/j.celrep.2021.109554
PMID: 34433059
PMC: PMC8411120

Art des Abschluß: -

Projektname : -

Grant ID : 170873

Förderprogramm : -

Förderorganisation : Swiss National Science Foundation (SNSF)

Projektname : -

Grant ID : DNRF117

Förderprogramm : -

Förderorganisation : Danish National Research Foundation (DNRF)

Projektname : -

Grant ID : 945539

Förderprogramm : -

Förderorganisation : Human Brain Project (HBP)

Projektname : -

Grant ID : 860563

Förderprogramm : -

Förderorganisation : European School of Network Neuroscience

Projektname : -

Grant ID : 001-P-001682

Förderprogramm : The Emerging Human Brain Cluster

Förderorganisation : -

Projektname : -

Grant ID : 201725.33

Förderprogramm : Brain-Connects

Förderorganisation : -

Projektname : -

Grant ID : APP1024800; APP1046198; APP1085404; APP1049596; DP140101560

Förderprogramm : -

Förderorganisation : National Health and Medical Research Council (NHMRC)

Projektname : Centre for Eudaimonia and Human Flourishing

Grant ID : -

Förderprogramm : -

Förderorganisation : Pettit and Carlsberg Foundations

Projektname : -

Grant ID : PID2019-105772GB-I00 MCIU AEI

Förderprogramm : -

Förderorganisation : Spanish Ministry of Science, Innovation and Universities (MCIU), State Research Agency (AEI)

Projektname : -

Grant ID : 2017 SGR 1545

Förderprogramm : -

Förderorganisation : Catalan Agency for Management of University and Research Grants (AGAUR)

Projektname : -

Grant ID : 101017716

Förderprogramm : Horizon 2020

Förderorganisation : European Union

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Titel: Cell Reports

Genre der Quelle: Zeitschrift

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Ort, Verlag, Ausgabe: Maryland Heights, MO : Cell Press

Seiten: - Band / Heft: 36 (8) Artikelnummer: 109554 Start- / Endseite: - Identifikator: ISSN: 2211-1247
CoNE: https://pure.mpg.de/cone/journals/resource/2211-1247

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