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  Parental relatedness through time revealed by runs of homozygosity in ancient DNA

Ringbauer, H., Novembre, J., & Steinrücken, M. (2021). Parental relatedness through time revealed by runs of homozygosity in ancient DNA. Nature Communications, 12: 5425. doi:10.1038/s41467-021-25289-w.

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Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Ringbauer, Harald1, Author                 
Novembre, John, Author
Steinrücken, Matthias, Author
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1Department of Archaeogenetics, Max Planck Institute for Evolutionary Anthropology, Max Planck Society, ou_3222712              

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 Abstract: Parental relatedness of present-day humans varies substantially across the globe, but little is known about the past. Here we analyze ancient DNA, leveraging that parental relatedness leaves genomic traces in the form of runs of homozygosity. We present an approach to identify such runs in low-coverage ancient DNA data aided by haplotype information from a modern phased reference panel. Simulation and experiments show that this method robustly detects runs of homozygosity longer than 4 centimorgan for ancient individuals with at least 0.3 × coverage. Analyzing genomic data from 1,785 ancient humans who lived in the last 45,000 years, we detect low rates of first cousin or closer unions across most ancient populations. Moreover, we find a marked decay in background parental relatedness co-occurring with or shortly after the advent of sedentary agriculture. We observe this signal, likely linked to increasing local population sizes, across several geographic transects worldwide.

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Language(s): eng - English
 Dates: 2021
 Publication Status: Published online
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 Rev. Type: Peer
 Identifiers: DOI: 10.1038/s41467-021-25289-w
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Title: Nature Communications
Source Genre: Journal
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Pages: - Volume / Issue: 12 Sequence Number: 5425 Start / End Page: - Identifier: ISBN: 2041-1723