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  Senile plaque calcification of the lamina circumvoluta medullaris in Alzheimer's disease

Schober, R., Hilbrich, I., Jäger, C., & Holzer, M. (2021). Senile plaque calcification of the lamina circumvoluta medullaris in Alzheimer's disease. Neuropathology, 41(5), 366-370. doi:10.1111/neup.12742.

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 Creators:
Schober, Ralf1, Author
Hilbrich, Isabel2, Author
Jäger, Carsten2, 3, Author           
Holzer, Max2, Author
Affiliations:
1Institute for Pathology, University Hospital Leipzig, Germany, ou_persistent22              
2Paul Flechsig Institute for Brain Research, University of Leipzig, Germany, ou_persistent22              
3Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2205649              

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Free keywords: Alzheimer's disease; Kosaka-Shibayama disease; Amyloid plaques; Diffuse neurofibrillary tangles with calcification
 Abstract: Vascular calcification is a common phenomenon in the elderly, predominantly appearing in the basal ganglia and in the lamina circumvoluta medullaris of the hippocampus. Calcifications are not an inherent feature of Alzheimer's disease. On the other hand, a rare presenile type of dementia with symmetrical Fahr-type calcifications and numerous neurofibrillary tangles without senile plaques has been described by Kosaka in 1994 and was termed "diffuse neurofibrillary tangles with calcification" (DNTC). We here report a case of Alzheimer's disease with calcifications both in the basal ganglia and in the lamina circumvoluta medullaris of the hippocampus, differing from DNTC by the presence of senile plaques. The calcifications in the hippocampus were not only vascular in nature but also covered amyloid-β- and phosphorylated tau-positive plaque-like structures that were linearly arranged along the dentate fascia in the CA1 sector, an unusual finding of pathogenetic interest.

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Language(s): eng - English
 Dates: 2021-08-202021-10
 Publication Status: Published in print
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 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1111/neup.12742
Other: epub 2021
PMID: 34415062
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Title: Neuropathology
Source Genre: Journal
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Publ. Info: Oxford : Wiley
Pages: - Volume / Issue: 41 (5) Sequence Number: - Start / End Page: 366 - 370 Identifier: ISSN: 1440-1789
CoNE: https://pure.mpg.de/cone/journals/resource/1440-1789