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  Genetic influences on hub connectivity of the human connectome

Arnatkeviciute, A., Fulcher, B. D., Oldham, S., Tiego, J., Paquola, C., Gerring, Z., et al. (2021). Genetic influences on hub connectivity of the human connectome. Nature Communications, 12(1): 4237. doi:10.1038/s41467-021-24306-2.

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 Creators:
Arnatkeviciute, Aurina1, Author
Fulcher, Ben D.1, 2, Author
Oldham, Stuart1, Author
Tiego, Jeggan1, Author
Paquola, Casey3, 4, Author
Gerring, Zachary5, Author
Aquino, Kevin1, 2, Author
Hawi, Ziarih1, Author
Johnson, Beth1, Author
Ball, Gareth6, 7, Author
Klein, Marieke8, 9, Author
Deco, Gustavo1, 10, 11, 12, 13, Author              
Franke, Barbara8, 14, Author
Bellgrove, Mark A.1, Author
Fornito, Alex1, Author
Affiliations:
1Turner Institute for Brain and Mental Health, Monash University, Melbourne, Australia, ou_persistent22              
2School of Physics, University of Sydney, Australia, ou_persistent22              
3McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, QC, Canada, ou_persistent22              
4Institute of Neuroscience and Medicine, Research Center Jülich, Germany, ou_persistent22              
5Translational Neurogenomics Laboratory, QIMR Berghofer Medical Research Institute, Brisbane, Australia, ou_persistent22              
6Developmental Imaging, Murdoch Childrens Research Institute, Melbourne, Australia, ou_persistent22              
7Department of Pediatrics, University of Melbourne, Australia, ou_persistent22              
8Department of Human Genetics, Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands, ou_persistent22              
9Department of Psychiatry, University of California San Diego, La Jolla, CA, USA, ou_persistent22              
10Department of Information and Communication Technologies, Center for Brain and Cognition, University Pompeu Fabra, Barcelona, Spain, ou_persistent22              
11University Pompeu Fabra, Barcelona, Spain, ou_persistent22              
12Catalan Institution for Research and Advanced Studies (ICREA), University Pompeu Fabra, Barcelona, Spain, ou_persistent22              
13Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634551              
14Department of Psychiatry, Radboud University, Nijmegen, the Netherlands, ou_persistent22              

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Free keywords: Computational neuroscience; Genetics of the nervous system; Neural circuits
 Abstract: Brain network hubs are both highly connected and highly inter-connected, forming a critical communication backbone for coherent neural dynamics. The mechanisms driving this organization are poorly understood. Using diffusion-weighted magnetic resonance imaging in twins, we identify a major role for genes, showing that they preferentially influence connectivity strength between network hubs of the human connectome. Using transcriptomic atlas data, we show that connected hubs demonstrate tight coupling of transcriptional activity related to metabolic and cytoarchitectonic similarity. Finally, comparing over thirteen generative models of network growth, we show that purely stochastic processes cannot explain the precise wiring patterns of hubs, and that model performance can be improved by incorporating genetic constraints. Our findings indicate that genes play a strong and preferential role in shaping the functionally valuable, metabolically costly connections between connectome hubs.

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 Dates: 2021-03-212021-06-032021-07-09
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1038/s41467-021-24306-2
PMID: 34244483
PMC: PMC8271018
 Degree: -

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Title: Nature Communications
  Abbreviation : Nat. Commun.
Source Genre: Journal
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Publ. Info: London : Nature Publishing Group
Pages: - Volume / Issue: 12 (1) Sequence Number: 4237 Start / End Page: - Identifier: ISSN: 2041-1723
CoNE: https://pure.mpg.de/cone/journals/resource/2041-1723