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  Lymphoid-specific helicase in epigenetics, DNA repair and cancer

Chen, X., Li, Y., Rubio, K., Deng, B., Li, Y., Tang, Q., et al. (2021). Lymphoid-specific helicase in epigenetics, DNA repair and cancer. BRITISH JOURNAL OF CANCER. doi:10.1038/s41416-021-01543-2.

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 Creators:
Chen, Xiangyu, Author
Li, Yamei, Author
Rubio, Karla1, Author              
Deng, Bi, Author
Li, Yuyi, Author
Tang, Qinwei, Author
Mao, Chao, Author
Liu, Shuang, Author
Xiao, Desheng, Author
Barreto, Guillermo1, Author              
Tao, Yongguang, Author
Affiliations:
1Lung Cancer Epigenetics, Max Planck Institute for Heart and Lung Research, Max Planck Society, ou_2591699              

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Free keywords: DOUBLE-STRAND BREAKS; SNF2 FAMILY-MEMBER; LSH; CHROMATIN; METHYLATION; COMPLEX; HELLS; METHYLTRANSFERASES; PROLIFERATION; RECOMBINATIONOncology;
 Abstract: Lymphoid-specific helicase (LSH) is a member of the SNF2 helicase family of chromatin-remodelling proteins. Dysfunctions or mutations in LSH causes an autosomal recessive disease known as immunodeficiency-centromeric instability-facial anomaly (ICF) syndrome. Interestingly, LSH participates in various aspects of epigenetic regulation, including nucleosome remodelling, DNA methylation, histone modifications and heterochromatin formation. Further, LSH plays a crucial role during DNA-damage repair, specifically during double-strand break (DSB) repair, since murine LSH was shown to be essential for non-homologous end joining (NHEJ) and homologous recombination (HR). Accordingly, overexpression of LSH drives tumorigenesis and malignancy. On the other hand, LSH homologs stabilise the genome. Thus, LSH might be implemented as a biomarker for various cancer types and potential target molecule to develop therapeutic strategies against them. In this review, we focus on the role of LSH in orchestrating chromatin rearrangements, such as DNA methylation and histone modifications, as well as in DNA-damage repair. Changes in chromatin structure may facilitate gene expression signatures that cause malignant transformation. We summarise recent findings of LSH in cancers and raise critical open questions for further studies.

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Language(s): eng - English
 Dates: 2021-09-07
 Publication Status: Published online
 Pages: 9
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: ISI: 000693516400001
DOI: 10.1038/s41416-021-01543-2
PMID: 34493821
 Degree: -

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Title: BRITISH JOURNAL OF CANCER
Source Genre: Journal
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Publ. Info: CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND : SPRINGERNATURE
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: - Identifier: ISSN: 0007-0920