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  Limited functional convergence of eye-specific inputs in the retinogeniculate pathway of the mouse

Bauer, J., Weiler, S., Fernholz, M. H. P., Laubender, D., Scheuss, V., Huebener, M., et al. (2021). Limited functional convergence of eye-specific inputs in the retinogeniculate pathway of the mouse. Neuron, 109(15), 2457-2468. doi:10.1016/j.neuron.2021.05.036.

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 Creators:
Bauer, Joel1, Author
Weiler, Simon1, Author              
Fernholz, Martin H. P.1, Author
Laubender, David, Author
Scheuss, Volker1, Author              
Huebener, Mark1, Author              
Bonhoeffer, Tobias1, Author              
Rose, Tobias1, Author              
Affiliations:
1Department: Synapses-Circuits-Plasticity / Bonhoeffer, MPI of Neurobiology, Max Planck Society, ou_1113545              

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Free keywords: LATERAL GENICULATE-NUCLEUS; PRIMARY VISUAL-CORTEX; OCULAR DOMINANCE; MONOCULAR DEPRIVATION; RELAY CELLS; PLASTICITY; RESPONSES; CIRCUITS; PRIMATE; PERIODNeurosciences & Neurology;
 Abstract: Segregation of retinal ganglion cell (RGC) axons by type and eye of origin is considered a hallmark of dorsal lateral geniculate nucleus (dLGN) structure. However, recent anatomical studies have shown that neurons in mouse dLGN receive input from multiple RGC types of both retinae. Whether convergent input leads to relevant functional interactions is unclear. We studied functional eye-specific retinogeniculate convergence using dual-color optogenetics in vitro. dLGN neurons were strongly dominated by input from one eye. Most neurons received detectable input from the non-dominant eye, but this input was weak, with a prominently reduced AMPAR:NMDAR ratio. Consistent with this, only a small fraction of thalamocortical neurons was binocular in vivo across visual stimuli and cortical projection layers. Anatomical overlap between RGC axons and dLGN neuron dendrites alone did not explain the strong bias toward monocularity. We conclude that functional eye-specific input selection and refinement limit convergent interactions in dLGN, favoring monocularity.

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Language(s): eng - English
 Dates: 2021
 Publication Status: Published in print
 Pages: 25
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Degree: -

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Title: Neuron
Source Genre: Journal
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Publ. Info: Cambridge, Mass. : Cell Press
Pages: - Volume / Issue: 109 (15) Sequence Number: - Start / End Page: 2457 - 2468 Identifier: ISSN: 0896-6273
CoNE: https://pure.mpg.de/cone/journals/resource/954925560565