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  Coronavirus-Replikation: Mechanismus und Inhibition durch Remdesivir

Cramer, P., Kokic, G., Dienemann, C., Höbartner, C., & Hillen, H. S. (2021). Coronavirus-Replikation: Mechanismus und Inhibition durch Remdesivir. Biospektrum, 27(1), 49-53. doi:10.1007/s12268-021-1516-6.

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 Creators:
Cramer, P.1, Author              
Kokic, G.1, Author              
Dienemann, C.1, Author              
Höbartner, C., Author
Hillen, H. S.2, Author              
Affiliations:
1Department of Molecular Biology, MPI for Biophysical Chemistry, Max Planck Society, ou_1863498              
2Research Group Structure and Function of Molecular Machines, MPI for Biophysical Chemistry, Max Planck Society, ou_3265856              

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 Abstract: Coronaviruses use an RNA-dependent RNA polymerase to replicate and transcribe their RNA genome. The structure of the SARS-CoV-2 poly- merase was determined by cryo-electron microscopy within a short time in spring 2020. The structure explains how the viral enzyme syn- thesizes RNA and how it replicates the exceptionally large genome in a processive manner. The most recent structure-function studies furtherreveal the mechanism of polymerase inhibition by remdesivir, an approved drug for the treatment of COVID-19.

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Language(s): deu - German
 Dates: 20212021
 Publication Status: Published in print
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 Rev. Type: Peer
 Identifiers: DOI: 10.1007/s12268-021-1516-6
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Title: Biospektrum
Source Genre: Journal
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Pages: - Volume / Issue: 27 (1) Sequence Number: - Start / End Page: 49 - 53 Identifier: -