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  The effects of nested miRNAs and their host genes on immune defense against Bacillus thuringiensis infection in Caenorhabditis elegans

Zárate-Potes, A., Yang, W., Andresen, B., Nakad, R., Haase, D., Rosenstiel, P., et al. (2021). The effects of nested miRNAs and their host genes on immune defense against Bacillus thuringiensis infection in Caenorhabditis elegans. Developmental & Comparative Immunology, 123: 104144. doi:10.1016/j.dci.2021.104144.

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 Creators:
Zárate-Potes, Alejandra, Author
Yang, Wentao, Author
Andresen, Bentje, Author
Nakad, Rania, Author
Haase, Daniela, Author
Rosenstiel, Philip, Author
Dierking, Katja, Author
Schulenburg, Hinrich1, Author           
Affiliations:
1Max Planck Fellow Group Antibiotic Resistance Evolution, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_2600692              

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Free keywords: Nested miRNAs, Host genes, Immune defenses
 Abstract: microRNAs (miRNAs) are small non-coding RNA-molecules that influence translation by binding to the target gene mRNA. Many miRNAs are found in nested arrangements within larger protein-coding host genes. miRNAs and host genes in a nested arrangement are often transcribed simultaneously, which may indicate that both have similar functions. miRNAs have been implicated in regulating defense responses against pathogen infection in C. elegans and in mammals. Here, we asked if miRNAs in nested arrangements and their host genes are involved in the C. elegans response against infection with Bacillus thuringiensis (Bt). We performed miRNA sequencing and subsequently focused on four nested miRNA-host gene arrangements for a functional genetic analysis. We identified mir-58.1 and mir-2 as negative regulators of C. elegans resistance to Bt infection. However, we did not find any miRNA/host gene pair in which both contribute to defense against Bt.

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Language(s): eng - English
 Dates: 2021-05-202021-03-092021-05-232021-05-272021-10
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1016/j.dci.2021.104144
 Degree: -

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Title: Developmental & Comparative Immunology
  Abbreviation : DCI
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Amsterdam [u.a.] : Elsevier
Pages: - Volume / Issue: 123 Sequence Number: 104144 Start / End Page: - Identifier: ISSN: 0145-305X
CoNE: https://pure.mpg.de/cone/journals/resource/0145-305X