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  CHD4 ensures stem cell lineage fidelity during skeletal muscle regeneration

Sreenivasan, K., Rodriguez-delaRosa, A., Kim, J., Mesquita, D., Segales, J., Gomez-del Arco, P., et al. (2021). CHD4 ensures stem cell lineage fidelity during skeletal muscle regeneration. STEM CELL REPORTS, 16(9), 2089-2098. doi:10.1016/j.stemcr.2021.07.022.

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 Creators:
Sreenivasan, Krishnamoorthy1, Author              
Rodriguez-delaRosa, Alejandra, Author
Kim, Johnny1, Author              
Mesquita, Diana, Author
Segales, Jessica, Author
Gomez-del Arco, Pablo, Author
Espejo, Isabel, Author
Ianni, Alessandro1, Author              
Di Croce, Luciano1, Author              
Relaix, Frederic, Author
Miguel Redondo, Juan, Author
Braun, Thomas1, Author              
Serrano, Antonio L., Author
Perdiguero, Eusebio, Author
Munoz-Canoves, Pura, Author
Affiliations:
1Cardiac Development and Remodeling, Max Planck Institute for Heart and Lung Research, Max Planck Society, ou_2591695              

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Free keywords: CHROMATIN REMODELER MI-2-BETA; HISTONE DEACETYLASE; DIFFERENTIATION; IDENTITY; EXPRESSION; COMPLEXES; NURDCell Biology;
 Abstract: Regeneration of skeletal muscle requires resident stem cells called satellite cells. Here, we report that the chromatin remodeler CHD4, a member of the nucleosome remodeling and deacetylase (NuRD) repressive complex, is essential for the expansion and regenerative functions of satellite cells. We show that conditional deletion of the Chd4 gene in satellite cells results in failure to regenerate muscle after injury. This defect is principally associated with increased stem cell plasticity and lineage infidelity during the expansion of satellite cells, caused by de-repression of non-muscle-cell lineage genes in the absence of Chd4. Thus, CHD4 ensures that a transcriptional program that safeguards satellite cell identity during muscle regeneration is maintained. Given the therapeutic potential of muscle stem cells in diverse neuromuscular pathologies, CHD4 constitutes an attractive target for satellite cell-based therapies.

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Language(s): eng - English
 Dates: 2021-08-262021-09-14
 Publication Status: Published in print
 Pages: 10
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Degree: -

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Title: STEM CELL REPORTS
Source Genre: Journal
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Publ. Info: 50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA : CELL PRESS
Pages: - Volume / Issue: 16 (9) Sequence Number: - Start / End Page: 2089 - 2098 Identifier: ISSN: 2213-6711