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  Behavioral, anatomical and heritable convergence of affect and cognition in superior frontal cortex

Kraljević, N., Schaare, H. L., Eickhoff, S. B., Kochunov, P., Yeo, B. T., Kharabian Masouleh, S., et al. (2021). Behavioral, anatomical and heritable convergence of affect and cognition in superior frontal cortex. NeuroImage, 243: 118561. doi:10.1016/j.neuroimage.2021.118561.

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 Creators:
Kraljević, Nevena1, 2, Author
Schaare, Herma Lina1, 3, Author              
Eickhoff, Simon B.1, 2, Author
Kochunov, Peter4, Author
Yeo, B.T. Thomas5, 6, 7, Author
Kharabian Masouleh, Shahrzad1, 2, Author
Valk, Sofie L.1, 2, 8, Author              
Affiliations:
1Institute of Neuroscience and Medicine, Research Center Jülich, Germany, ou_persistent22              
2Institute of Systems Neuroscience, University Hospital Düsseldorf, Germany, ou_persistent22              
3Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
4Maryland Psychiatric Research Center (MPRC), University of Maryland School of Medicine, Baltimore, MD, USA, ou_persistent22              
5Department of Electrical and Computer Engineering, Clinical Imaging Research Centre, National University of Singapore, ou_persistent22              
6Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA, USA, ou_persistent22              
7NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, ou_persistent22              
8Otto Hahn Group Cognitive Neurogenetics, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_3222264              

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Free keywords: Affect; Cognition; Cortical structure; Frontal cortex; Genetic correlation; Heritability
 Abstract: Cognitive abilities and affective experience are key human traits that are interrelated in behavior and brain. Individual variation of cognitive and affective traits, as well as brain structure, has been shown to partly underlie genetic effects. However, to what extent affect and cognition have a shared genetic relationship with local brain structure is incompletely understood. Here we studied phenotypic and genetic correlations of cognitive and affective traits in behavior and brain structure (cortical thickness, surface area and subcortical volumes) in the pedigree-based Human Connectome Project sample (N = 1091). Both cognitive and affective trait scores were highly heritable and showed significant phenotypic correlation on the behavioral level. Cortical thickness in the left superior frontal cortex showed a phenotypic association with both affect and cognition. Decomposing the phenotypic correlations into genetic and environmental components showed that the associations were accounted for by shared genetic effects between the traits. Quantitative functional decoding of the left superior frontal cortex further indicated that this region is associated with cognitive and emotional functioning. This study provides a multi-level approach to study the association between affect and cognition and suggests a convergence of both in superior frontal cortical thickness.

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 Dates: 2021-08-312021-07-082021-09-062021-09-072021-11
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1016/j.neuroimage.2021.118561
Other: online ahead of print
PMID: 34506912
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Project name : -
Grant ID : 945539
Funding program : Horizon 2020
Funding organization : European Union
Project name : -
Grant ID : NUHSRO/2020/124/TMR/LOA
Funding program : -
Funding organization : National University of Singapore

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Title: NeuroImage
Source Genre: Journal
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Publ. Info: Orlando, FL : Academic Press
Pages: - Volume / Issue: 243 Sequence Number: 118561 Start / End Page: - Identifier: ISSN: 1053-8119
CoNE: https://pure.mpg.de/cone/journals/resource/954922650166