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  Activity-dependent TMS: Combination of spatial and temporal information

Novikov, P., Nazarova, M., Reshetnikov, M., Kozlova, K., Makarova, M., & Nikulin, V. V. (2021). Activity-dependent TMS: Combination of spatial and temporal information. Psychology: Journal of the Higher School of Economics, 18(2), 381-392. doi:10.17323/1813-8918-2021-2-381-392.

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 Creators:
Novikov, Pavel1, Author
Nazarova, Maria1, 2, Author
Reshetnikov, Mikhail1, Author
Kozlova, Kseniia1, Author
Makarova, Milana1, Author
Nikulin, Vadim V.1, 3, Author              
Affiliations:
1National Research University Higher School of Economics, Moscow, Russia, ou_persistent22              
2Federal Medical-Biological Agency (FMBA), Moscow, Russia, ou_persistent22              
3Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              

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Free keywords: Software; Neuronavigation; Activity-dependent stimulation; Transcranial magnetic stimulation (TMS); Electromyography (EMG); Latency
 Abstract: Transcranial magnetic stimulation (TMS) is a non-invasive method allowing both investigating and modulating human brain in normal and pathological conditions. One of the most serious problems limiting TMS use in research and clinical practice is the high variability of its effects. In recent years, it became widely accepted that the effects of TMS protocols is not just a property of a TMS protocol itself, but a consequence of the interactions of the intervention with the individual neuronal phenotype and ongoing functional state, which is primarily based on the ongoing neuronal activity. Thus, it is necessary to develop TMS approaches that take into account the ongoing neuronal activity, the so-called state/activity-dependent TMS. Here we present software that allows considering both the position of the magnetic stimulator and the ongoing biological activity for the purpose of TMS triggering. The software allows automatic TMS triggering when several conditions are met: the beginning of the movement/activation of a target muscle, lack of the preactivation of a non-target muscle and a correct positioning of a magnetic coil. The novelty of the developed neuronavigation software is due to a combination of spatial information about the position of a magnetic coil ("where?") and temporal information about the ongoing biological activity ("when?"). The time lag for the stimulation triggering was tested in an experiment with TMS triggered by a movement onset; and it was about 20 ms. Further software development is planned towards the introduction of EEG-dependent TMS approaches. The latency for TMS triggering was tested in an experiment with TMS triggered by a movement onset. In the future implementation of EEG-based TMS approaches is planned. We believe that the development of such a technical solution for neuronavigated activity-dependent TMS is important to bring TMS methodology to a new level of the spatio-temporal specificity.

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 Dates: 2021-06-302021
 Publication Status: Published in print
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 Identifiers: DOI: 10.17323/1813-8918-2021-2-381-392
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Title: Psychology: Journal of the Higher School of Economics
Source Genre: Journal
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Publ. Info: Moscow : Higher School of Economics
Pages: - Volume / Issue: 18 (2) Sequence Number: - Start / End Page: 381 - 392 Identifier: ISSN: 1813-8918
CoNE: https://pure.mpg.de/cone/journals/resource/1813-8918