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  Cross-reactive CD4+ T cells enhance SARS-CoV-2 immune responses upon infection and vaccination

Loyal, L., Braun, J., Henze, L., Kruse, B., Dingeldey, M., Reimer, U., et al. (2021). Cross-reactive CD4+ T cells enhance SARS-CoV-2 immune responses upon infection and vaccination. Science. doi:10.1126/science.abh1823.

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 Creators:
Loyal, Lucie , Author
Braun, Julian , Author
Henze, Larissa , Author
Kruse, Beate, Author
Dingeldey, Manuela , Author
Reimer, Ulf, Author
Kern, Florian, Author
Schwarz, Tatjana, Author
Mangold, Meike, Author
Unger, Clara, Author
Dörfler, Friederike , Author
Kadler, Shirin, Author
Rosowski, Jennifer , Author
Gürcan, Kübrah , Author
Uyar-Aydin, Zehra , Author
Frentsch, Marco , Author
Kurth, Florian, Author
Schnatbaum, Karsten , Author
Eckey, Maren, Author
Hippenstiel, Stefan , Author
Hocke, Andreas, AuthorMüller, Marcel A. , AuthorSawitzki, Birgit, AuthorMiltenyi, Stefan , AuthorFriedemann, Paul, AuthorMall, Marcus A. , AuthorWenschuh, Holger, AuthorVoigt, Sebastian , AuthorDrosten, Christian, AuthorLauster, Roland , AuthorLachman, Nils, AuthorSander , Leif-Erik , AuthorCorman, Victor M. , AuthorRöhmel, Jobst, AuthorMeyer-Arndt, Lil, AuthorThiel, Andreas, AuthorGiesecke-Thiel, Claudia1, Author               more..
Affiliations:
1Flow Cytometry Facility (Head: Claudia Giesecke-Thiel), Scientific Service (Head: Christoph Krukenkamp), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_3039333              

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 Abstract: The functional relevance of pre-existing cross-immunity to SARS-CoV-2 is a subject of intense debate. Here, we show that human endemic coronavirus (HCoV)-reactive and SARS-CoV-2-cross-reactive CD4+ T cells are ubiquitous but decrease with age. We identified a universal immunodominant coronavirus-specific spike peptide (S816-830) and demonstrate that pre-existing spike- and S816-830-reactive T cells were recruited into immune responses to SARS-CoV-2 infection and their frequency correlated with anti-SARS-CoV-2-S1-IgG antibodies. Spike-cross-reactive T cells were also activated after primary BNT162b2 COVID-19 mRNA vaccination displaying kinetics similar to secondary immune responses. Our results highlight the functional contribution of pre-existing spike-cross-reactive T cells in SARS-CoV-2 infection and vaccination. Cross-reactive immunity may account for the unexpectedly rapid induction of immunity following primary SARS-CoV-2 immunization and the high rate of asymptomatic/mild COVID-19 disease courses.

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Language(s): eng - English
 Dates: 2021-08-242021-08-31
 Publication Status: Published online
 Pages: -
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 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1126/science.abh1823
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Title: Science
  Abbreviation : Science
Source Genre: Journal
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Publ. Info: Washington, D.C. : American Association for the Advancement of Science
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: - Identifier: ISSN: 0036-8075
CoNE: https://pure.mpg.de/cone/journals/resource/991042748276600_1