English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Developmental Control of Synaptic Receptivity

Barker, A. J., Koch, S. M., Reed, J., Barres, B. A., & Ullian, E. M. (2008). Developmental Control of Synaptic Receptivity. J. Neurosci., 28(33), 8150-8160. doi:10.1523/JNEUROSCI.1744-08.2008.

Item is

Basic

show hide
Genre: Journal Article

Files

show Files

Locators

show
hide
Description:
-

Creators

show
hide
 Creators:
Barker, Alison J.1, 2, Author              
Koch, Selina M. , Author
Reed, Jamian , Author
Barres, Ben A. , Author
Ullian, Erik M., Author
Affiliations:
1Social Systems and Circuits Group, Max Planck Institute for Brain Research, Max Planck Society, ou_3334049              
2Department of Ophthalmology, University of California, San Francisco, San Francisco, California 94143-0730, USA., ou_persistent22              

Content

show
hide
Free keywords: synaptogenesis retinal ganglion cells (RGCs) astrocytes glia dendrite arborization rat
 Abstract: Are neurons born with the ability to form and receive synapses or do they acquire these abilities during development? We have previously found that purified postnatal retinal ganglion cells (RGCs) require soluble astrocyte-derived signals to form synapses in vitro and in vivo. Here we show that newly generated embryonic day 17 (E17) RGCs are able to form but not receive synapses under these conditions. Dendrite growth is not sufficient to trigger receptivity; rather, the ability of newly generated RGCs to receive synapses is acquired at E19 in response to direct contact by neighboring cell types. Direct contact with astrocytes, which are not present at E17 but are normally generated by E19, is sufficient to induce synaptic receptivity in E17 RGCs. In contrast, amacrine contact does not induce synaptic receptivity. Interestingly, astrocyte contact alters the localization of the synaptic adhesion molecule neurexin away from dendrites. In addition, dendritic expression of neurexin is sufficient to prevent astrocyte contact-mediated increases in synapse number, suggesting a molecular mechanism by which astrocyte contact regulates neuronal synaptic receptivity. Thus, synaptic receptivity is not induced simply by dendritic elaboration but must be signaled by both contact-mediated signaling from astrocytes and a shift in the dendritic localization of neurexin.

Details

show
hide
Language(s): eng - English
 Dates: 2006-12-042008-06-262008-08-13
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1523/JNEUROSCI.1744-08.2008
PMID: 18701677
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: J. Neurosci.
  Other : The Journal of Neuroscience: the Official Journal of the Society for Neuroscience
  Abbreviation : J. Neurosci.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Washington, DC : Society of Neuroscience
Pages: - Volume / Issue: 28 (33) Sequence Number: - Start / End Page: 8150 - 8160 Identifier: ISSN: 0270-6474
CoNE: https://pure.mpg.de/cone/journals/resource/954925502187_1