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  Reversible reprogramming of cardiomyocytes to a fetal state drives heart regeneration in mice

Chen, Y., Luttmann, F. F., Schoger, E., Schoeler, H. R., Zelarayan, L. C., Kim, K.-P., et al. (2021). Reversible reprogramming of cardiomyocytes to a fetal state drives heart regeneration in mice. SI, 373(6562), 1537-1540. doi:10.1126/science.abg5159.

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Genre: Journal Article

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 Creators:
Chen, Yanpu1, Author              
Luttmann, Felipe F.1, Author              
Schoger, Eric, Author
Schoeler, Hans R., Author
Zelarayan, Laura C., Author
Kim, Kee-Pyo, Author
Haigh, Jody J., Author
Kim, Johnny1, Author              
Braun, Thomas1, Author              
Affiliations:
1Cardiac Development and Remodeling, Max Planck Institute for Heart and Lung Research, Max Planck Society, ou_2591695              

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Free keywords: MOUSEScience & Technology - Other Topics;
 Abstract: Cardiomyocyte (CM) replacement is very slow in adultmammalian hearts, preventing regeneration of damaged myocardium. By contrast, fetal hearts display considerable regenerative potential owing to the presence of less mature CMs that still have the ability to proliferate. In this study, we demonstrate that heart-specific expression of Oct4, Sox2, Klf4, and c-Myc (OSKM) induces adult CMs to dedifferentiate, conferring regenerative capacity to adult hearts. Transient, CM-specific expression of OSKM extends the regenerative window for postnatal mouse hearts and induces a gene expression program in adult CMs that resembles that of fetal CMs. Extended expression of OSKM in CMs leads to cellular reprogramming and heart tumor formation. Short-term OSKM expression before and during myocardial infarction ameliorates myocardial damage and improves cardiac function, demonstrating that temporally controlled dedifferentiation and reprogramming enable cell cycle reentry of mammalian CMs and facilitate heart regeneration.

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Language(s): eng - English
 Dates: 2021-09-232021-09-24
 Publication Status: Published in print
 Pages: 39
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: ISI: 000698977800056
DOI: 10.1126/science.abg5159
PMID: 34554778
 Degree: -

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Title: SI
Source Genre: Issue
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Publ. Info: 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA : AMER ASSOC ADVANCEMENT SCIENCE
Pages: - Volume / Issue: 373 (6562) Sequence Number: - Start / End Page: 1537 - 1540 Identifier: ISSN: 0036-8075

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Title: SCIENCE
  Alternative Title : SCIENCE
  Alternative Title : Science
Source Genre: Journal
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Publ. Info: -
Pages: - Volume / Issue: 373 (6562) Sequence Number: - Start / End Page: 1537 - 1540 Identifier: -