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  SIRT7 Acts as a Guardian of Cellular Integrity by Controlling Nucleolar and Extra-Nucleolar Functions

Kumari, P., Tarighi, S., Braun, T., & Ianni, A. (2021). SIRT7 Acts as a Guardian of Cellular Integrity by Controlling Nucleolar and Extra-Nucleolar Functions. GENES, 12(9): 1361. doi:10.3390/genes12091361.

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Genre: Journal Article

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 Creators:
Kumari, Poonam1, Author              
Tarighi, Shahriar1, Author              
Braun, Thomas1, Author              
Ianni, Alessandro1, Author              
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1Cardiac Development and Remodeling, Max Planck Institute for Heart and Lung Research, Max Planck Society, ou_2591695              

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Free keywords: RNA-POLYMERASE-I; RIBOSOME BIOGENESIS; CALORIE RESTRICTION; STRESS; RDNA; SIRTUINS; DEACETYLATION; METHYLATION; ACTIVATION; CANCERGenetics & Heredity; sirtuins; SIRT7; deacetylation; stress responses; nucleolus;
 Abstract: Sirtuins are key players for maintaining cellular homeostasis and are often deregulated in different human diseases. SIRT7 is the only member of mammalian sirtuins that principally resides in the nucleolus, a nuclear compartment involved in ribosomal biogenesis, senescence, and cellular stress responses. The ablation of SIRT7 induces global genomic instability, premature ageing, metabolic dysfunctions, and reduced stress tolerance, highlighting its critical role in counteracting ageing-associated processes. In this review, we describe the molecular mechanisms employed by SIRT7 to ensure cellular and organismal integrity with particular emphasis on SIRT7-dependent regulation of nucleolar functions.

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Language(s): eng - English
 Dates: 2021-08-30
 Publication Status: Published online
 Pages: 13
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: ISI: 000699551700001
DOI: 10.3390/genes12091361
PMID: 34573343
 Degree: -

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Title: GENES
Source Genre: Journal
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Publ. Info: ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND : MDPI
Pages: - Volume / Issue: 12 (9) Sequence Number: 1361 Start / End Page: - Identifier: -