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  Gut microbiota link dietary fiber intake and short-chain fatty acid metabolism with eating behavior

Medawar, E., Haange, S.-B., Rolle-Kampczyk, U., Engelmann, B., Dietrich, A., Thieleking, R., et al. (2021). Gut microbiota link dietary fiber intake and short-chain fatty acid metabolism with eating behavior. Translational Psychiatry, 11(1): 500. doi:10.1038/s41398-021-01620-3.

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Medawar, Evelyn1, 2, 3, Author              
Haange, Sven-Bastiaan4, Author
Rolle-Kampczyk, Ulrike4, Author
Engelmann, Beatrice4, Author
Dietrich, Arne5, Author
Thieleking, Ronja1, Author              
Wiegank, Charlotte1, Author
Fries, Charlotte6, Author
Horstmann, Annette1, 7, 8, Author              
Villringer, Arno1, 3, 9, Author              
von Bergen, Martin4, 10, Author
Fenske, Wiebke6, Author
Witte, A. Veronica1, 9, Author              
Affiliations:
1Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_634549              
2Berlin School of Mind and Brain, Humboldt University Berlin, Germany, ou_persistent22              
3Charité University Medicine Berlin, Germany, ou_persistent22              
4Department of Molecular Systems Biology, Helmholtz Centre for Environmental Research (UfZ), Leipzig, Germany, ou_persistent22              
5Department of Visceral and Metabolic Surgery, University Hospital Leipzig, Germany, ou_persistent22              
6Department of Endocrinology, Diabetes and Metabolism, University Hospital Bonn, Germany, ou_persistent22              
7Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Finland, ou_persistent22              
8Faculty of Medicine, University of Leipzig, Germany, ou_persistent22              
9Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              
10Institute of Biochemistry, University of Leipzig, Germany, ou_persistent22              

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 Abstract: The gut microbiome has been speculated to modulate feeding behavior through multiple factors, including short-chain fatty acids (SCFA). Evidence on this relationship in humans is however lacking. We aimed to explore if specific bacterial genera relate to eating behavior, diet, and SCFA in adults. Moreover, we tested whether eating-related microbiota relate to treatment success in patients after Roux-en-Y gastric bypass (RYGB). Anthropometrics, dietary fiber intake, eating behavior, 16S-rRNA-derived microbiota, and fecal and serum SCFA were correlated in young overweight adults (n = 27 (9 F), 21–36 years, BMI 25–31 kg/m2). Correlated genera were compared in RYGB (n = 23 (16 F), 41–70 years, BMI 25–62 kg/m2) and control patients (n = 17 (11 F), 26–69 years, BMI 25–48 kg/m2). In young adults, 7 bacteria genera, i.e., Alistipes, Blautia, Clostridiales cluster XVIII, Gemmiger, Roseburia, Ruminococcus, and Streptococcus, correlated with healthier eating behavior, while 5 genera, i.e., Clostridiales cluster IV and XIVb, Collinsella, Fusicatenibacter, and Parabacteroides, correlated with unhealthier eating (all | r | > 0.4, FDR-corrected p < 0.05). Some of these genera including Parabacteroides related to fiber intake and SCFA, and to weight status and treatment response in overweight/obese patients. In this exploratory analysis, specific bacterial genera, particularly Parabacteroides, were associated with weight status and eating behavior in two small, independent and well-characterized cross-sectional samples. These preliminary findings suggest two groups of presumably beneficial and unfavorable genera that relate to eating behavior and weight status, and indicate that dietary fiber and SCFA metabolism may modify these relationships. Larger interventional studies are needed to distinguish correlation from causation.

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 Dates: 2021-08-312021-05-032021-09-132021-10-01
 Publication Status: Published online
 Pages: -
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 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1038/s41398-021-01620-3
PMID: 34599144
PMC: PMC8486801
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Title: Translational Psychiatry
  Abbreviation : Transl Psychiatry
Source Genre: Journal
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Publ. Info: Nature Pub. Group
Pages: - Volume / Issue: 11 (1) Sequence Number: 500 Start / End Page: - Identifier: ISSN: 2158-3188
CoNE: https://pure.mpg.de/cone/journals/resource/2158-3188