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  Effect of stimulus orientation and intensity on short-interval intracortical inhibition (SICI) and facilitation (SICF): A multi-channel transcranial magnetic stimulation study

Tugin, S., Souza, V. H., Nazarova, M. A., Novikov, P. A., Tervo, A. E., Nieminen, J. O., et al. (2021). Effect of stimulus orientation and intensity on short-interval intracortical inhibition (SICI) and facilitation (SICF): A multi-channel transcranial magnetic stimulation study. PLoS One, 16(9): e0257554. doi:10.1371/journal.pone.0257554.

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Tugin, Sergei1, 2, Author
Souza, Victor H.1, 2, 3, Author
Nazarova, Maria A.4, 5, Author
Novikov, Pavel A.4, Author
Tervo, Aino E.1, 2, Author
Nieminen, Jaakko O.1, 2, Author
Lioumis, Pantelis1, 2, Author
Ziemann, Ulf6, 7, Author
Nikulin, Vadim V.4, 8, Author           
Ilmoniemi, Risto J.1, 2, Author
1Department of Neuroscience and Biomedical Engineering, Aalto University, Espoo, Finland, ou_persistent22              
2BioMag Laboratory, Helsinki University Hospital, Finland, ou_persistent22              
3School of Physiotherapy, Federal University of Juiz de Fora, Brazil, ou_persistent22              
4Centre for Cognition and Decision Making, National Research University Higher School of Economics, Moscow, Russia, ou_persistent22              
5Federal Medical-Biological Agency (FMBA), Moscow, Russia, ou_persistent22              
6Department of Neurology and Stroke, Eberhard Karls University Tübingen, Germany, ou_persistent22              
7Hertie-Institute for Clinical Brain Research, Eberhard Karls University Tübingen, Germany, ou_persistent22              
8Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              


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 Abstract: Besides stimulus intensities and interstimulus intervals (ISI), the electric field (E-field) orientation is known to affect both short-interval intracortical inhibition (SICI) and facilitation (SICF) in paired-pulse transcranial magnetic stimulation (TMS). However, it has yet to be established how distinct orientations of the conditioning (CS) and test stimuli (TS) affect the SICI and SICF generation. With the use of a multi-channel TMS transducer that provides electronic control of the stimulus orientation and intensity, we aimed to investigate how changes in the CS and TS orientation affect the strength of SICI and SICF. We hypothesized that the CS orientation would play a major role for SICF than for SICI, whereas the CS intensity would be more critical for SICI than for SICF. In eight healthy subjects, we tested two ISIs (1.5 and 2.7 ms), two CS and TS orientations (anteromedial (AM) and posteromedial (PM)), and four CS intensities (50, 70, 90, and 110% of the resting motor threshold (RMT)). The TS intensity was fixed at 110% RMT. The intensities were adjusted to the corresponding RMT in the AM and PM orientations. SICI and SICF were observed in all tested CS and TS orientations. SICI depended on the CS intensity in a U-shaped manner in any combination of the CS and TS orientations. With 70% and 90% RMT CS intensities, stronger PM-oriented CS induced stronger inhibition than weaker AM-oriented CS. Similar SICF was observed for any CS orientation. Neither SICI nor SICF depended on the TS orientation. We demonstrated that SICI and SICF could be elicited by the CS perpendicular to the TS, which indicates that these stimuli affected either overlapping or strongly connected neuronal populations. We concluded that SICI is primarily sensitive to the CS intensity and that CS intensity adjustment resulted in similar SICF for different CS orientations.


Language(s): eng - English
 Dates: 2021-05-242021-09-032021-09-22
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1371/journal.pone.0257554
Other: eCollection 2021
PMID: 34550997
PMC: PMC8457500
 Degree: -



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Project name : -
Grant ID : 810377
Funding program : Horizon 2020
Funding organization : European Union
Project name : -
Grant ID : 294625, 306845, and 327326
Funding program : -
Funding organization : Jane and Aatos Erkko Foundation

Source 1

Title: PLoS One
Source Genre: Journal
Publ. Info: San Francisco, CA : Public Library of Science
Pages: - Volume / Issue: 16 (9) Sequence Number: e0257554 Start / End Page: - Identifier: ISSN: 1932-6203
CoNE: https://pure.mpg.de/cone/journals/resource/1000000000277850