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Free keywords:
Binding Sites, Electron Transport Complex IV, Escherichia coli Proteins, Fungal Proteins, Humans, Membrane Proteins, Membrane Transport Proteins, Mitochondrial Proteins, Models, Molecular, Nuclear Proteins, Protein Binding, Protein Domains, Substrate Specificity
Abstract:
Members of the Oxa1 superfamily perform membrane protein insertion in bacteria, the eukaryotic endoplasmic reticulum (ER), and endosymbiotic organelles. Here, we review recent structures of the three ER-resident insertases and discuss the extent to which structure and function are conserved with their bacterial counterpart YidC.
