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  Identification of neurobehavioural symptom groups based on shared brain mechanisms

Ing, A., Saemann, P. G., Chu, C., Tay, N., Biondo, F., Robertl, G., et al. (2019). Identification of neurobehavioural symptom groups based on shared brain mechanisms. NATURE HUMAN BEHAVIOUR, 3(12), 1306-1318. doi:10.1038/s41562-019-0738-8.

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 Creators:
Ing, Alex, Author
Saemann, Philipp G.1, Author           
Chu, Congying, Author
Tay, Nicole, Author
Biondo, Francesca, Author
Robertl, Gabriel, Author
Jia, Tianye, Author
Wolfers, Thomas, Author
Desrivieres, Sylvane, Author
Banaschewski, Tobias, Author
Bokde, Arun L. W., Author
Bromberg, Uli, Author
Buechel, Christian, Author
Conrod, Patricia, Author
Fadai, Tahmine, Author
Flor, Herta, Author
Frouin, Vincent, Author
Garavan, Hugh, Author
Spechler, Philip A., Author
Gowlandl, Penny, Author
Grimmer, Yvonne, AuthorHeinz, Andreas, AuthorIttermann, Bernd, AuthorKappel, Viola, AuthorMartinot, Jean-Luc, AuthorMeyer-Lindenberg, Andreas, AuthorMillenets, Sabina, AuthorNeess, Frauke, Authorvan Noort, Betteke, AuthorOrfanos, Dimitri Papadopoulos, AuthorMartinot, Marie-Laure Paillere, AuthorPenttilae, Jani, AuthorPoustka, Luise, AuthorQuinlan, Erin Burke, AuthorSmolka, Michael N., AuthorStringaris, Argyris, AuthorStruve, Maren, AuthorVeer, Ilya M., AuthorWalter, Henrik, AuthorWhelan, Robert, AuthorAndreassen, Ole A., AuthorAgartz, Ingrid, AuthorLemaitre, Herve, AuthorBarker, Edward D., AuthorAshburner, John, AuthorBinder, Elisabeth2, Author           Buitelaar, Jan, AuthorMarquand, Andre, AuthorRobbins, Trevor W., AuthorSchumann, Gunter, Author more..
Affiliations:
1Max Planck Institute of Psychiatry, Max Planck Society, ou_1607137              
2Dept. Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Max Planck Society, ou_2035295              

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 Abstract: Most psychopathological disorders develop in adolescence. The biological basis for this development is poorly understood. To enhance diagnostic characterization and develop improved targeted interventions, it is critical to identify behavioural symptom groups that share neural substrates. We ran analyses to find relationships between behavioural symptoms and neuroimaging measures of brain structure and function in adolescence. We found two symptom groups, consisting of anxiety/depression and executive dysfunction symptoms, respectively, that correlated with distinct sets of brain regions and inter-regional connections, measured by structural and functional neuroimaging modalities. We found that the neural correlates of these symptom groups were present before behavioural symptoms had developed. These neural correlates showed case-control differences in corresponding psychiatric disorders, depression and attention deficit hyperactivity disorder in independent clinical samples. By characterizing behavioural symptom groups based on shared neural mechanisms, our results provide a framework for developing a classification system for psychiatric illness that is based on quantitative neurobehavioural measures.

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 Dates: 2019
 Publication Status: Issued
 Pages: -
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 Rev. Type: -
 Identifiers: ISI: 000502379800017
DOI: 10.1038/s41562-019-0738-8
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Title: NATURE HUMAN BEHAVIOUR
Source Genre: Journal
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Pages: - Volume / Issue: 3 (12) Sequence Number: - Start / End Page: 1306 - 1318 Identifier: ISSN: 2397-3374