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  The genetic relationship between educational attainment and cognitive performance in major psychiatric disorders

Comes, A. L., Senner, F., Budde, M., Adorjan, K., Anderson-Schmidt, H., Andlauer, T. F. M., et al. (2019). The genetic relationship between educational attainment and cognitive performance in major psychiatric disorders. TRANSLATIONAL PSYCHIATRY, 9: 210. doi:10.1038/s41398-019-0547-x.

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Comes, Ashley L.1, Author           
Senner, Fanny, Author
Budde, Monika, Author
Adorjan, Kristina, Author
Anderson-Schmidt, Heike, Author
Andlauer, Till F. M., Author
Gade, Katrin, Author
Hake, Maria, Author
Heilbronner, Urs, Author
Kalman, Janos L.1, Author           
Reich-Erkelenz, Daniela, Author
Kloehn-Saghatolislam, Farah, Author
Schaupp, Sabrina K., Author
Schulte, Eva C., Author
Juckel, Georg, Author
Dannlowski, Udo, Author
Schmauss, Max, Author
Zimmermann, Joerg, Author
Reimer, Jens, Author
Reininghaus, Eva, Author
Anghelescu, Ion-George, AuthorArolt, Volker, AuthorBaune, Bernhard T., AuthorKonrad, Carsten, AuthorThiel, Andreas, AuthorFallgatter, Andreas J., AuthorNieratschker, Vanessa, AuthorFigge, Christian, Authorvon Hagen, Martin, AuthorKoller, Manfred, AuthorBecker, Thomas, AuthorWigand, Moritz E., AuthorJaeger, Markus, AuthorDietrich, Detlef E., AuthorStierl, Sebastian, AuthorScherk, Harald, AuthorSpitzer, Carsten, AuthorFolkerts, Here, AuthorWitt, Stephanie H., AuthorDegenhardt, Franziska, AuthorForstner, Andreas J., AuthorRietschel, Marcella, AuthorNoethen, Markus M., AuthorWiltfang, Jens, AuthorFalkai, Peter, AuthorSchulze, Thomas G., AuthorPapiol, Sergi, Author more..
Affiliations:
1IMPRS Translational Psychiatry, Max Planck Institute of Psychiatry, Max Planck Society, ou_3318616              

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 Abstract: Cognitive deficits are a core feature of psychiatric disorders like schizophrenia and bipolar disorder. Evidence supports a genome-wide polygenic score (GPS) for educational attainment (GPS(EDu)) can be used to explain variability in cognitive performance. We aimed to identify different cognitive domains associated with GPS(EDu) in a transdiagnostic clinical cohort of chronic psychiatric patients with known cognitive deficits. Bipolar and schizophrenia patients from the PsyCourse cohort (N= 730; 43% female) were used. Likewise, we tested whether GPSs for schizophrenia (GPS(sz)) and bipolar disorder (GPS(BD)) were associated with cognitive outcomes. GPS(EDu) explained 1.5% of variance in the backward verbal digit span, 1.9% in the number of correctly recalled words of the Verbal Learning and Memory Test, and 1.1% in crystallized intelligence. These effects were robust to the influences of treatment and diagnosis. No significant associations between GPS(sz) or GPS(BD )with cognitive outcomes were found. Furthermore, these risk scores did not confound the effect of GPS(EDu) on cognitive outcomes. GPS(EDu) explains a small fraction of cognitive performance in adults with psychiatric disorders, specifically for domains related to linguistic learning and working memory. Investigating such a proxy-phenotype longitudinally, could give intriguing insight into the disease course, highlighting at what time genes play a more influential role on cognitive performance. Better understanding the origin of these deficits might help identify those patients at risk for lower levels of functioning and poor social outcomes. Polygenic estimates may in the future be part of predictive models for more personalized interventions.

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 Dates: 2019
 Publication Status: Published online
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 Rev. Type: -
 Identifiers: ISI: 000483954400001
DOI: 10.1038/s41398-019-0547-x
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Title: TRANSLATIONAL PSYCHIATRY
Source Genre: Journal
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Pages: - Volume / Issue: 9 Sequence Number: 210 Start / End Page: - Identifier: ISSN: 2158-3188