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  Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns

Czamara, D., Eraslan, G., Page, C. M., Lahti, J., Lahti-Pulkkinen, M., Hamalainen, E., et al. (2019). Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns. NATURE COMMUNICATIONS, 10: 2548. doi:10.1038/s41467-019-10461-0.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0009-6F82-8 Version Permalink: https://hdl.handle.net/21.11116/0000-0009-6F83-7
Genre: Journal Article

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Czamara, Darina1, Author           
Eraslan, Goekcen2, Author
Page, Christian M.2, Author
Lahti, Jari2, Author
Lahti-Pulkkinen, Marius2, Author
Hamalainen, Esa2, Author
Kajantie, Eero2, Author
Laivuori, Hannele2, Author
Villa, Pia M.2, Author
Reynolds, Rebecca M.2, Author
Nystad, Wenche2, Author
Haberg, Siri E.2, Author
London, Stephanie J.2, Author
O'Donnell, Kieran J.2, Author
Garg, Elika2, Author
Meaney, Michael J.2, Author
Entringer, Sonja2, Author
Wadhwa, Pathik D.2, Author
Buss, Claudia2, Author
Jones, Meaghan J.2, Author
Lin, David T. S.2, AuthorMacIsaac, Julie L.2, AuthorKobor, Michael S.2, AuthorKoen, Nastassja2, AuthorZar, Heather J.2, AuthorKoenen, Karestan C.2, AuthorDalvie, Shareefa2, AuthorStein, Dan J.2, AuthorKondofersky, Ivan2, AuthorMueller, Nikola S.2, AuthorTheis, Fabian J.2, AuthorRaikkonen, Katri2, AuthorBinder, Elisabeth B.1, Author           Wray, Naomi R.2, AuthorRipke, Stephan2, AuthorMattheisen, Manuel2, AuthorTrzaskowski, Maciej2, AuthorByrne, Enda M.2, AuthorAbdellaoui, Abdel2, AuthorAdams, Mark J.2, AuthorAgerbo, Esben2, AuthorAir, Tracy M.2, AuthorAndlauer, Till F. M.1, Author           Bacanu, Silviu-Alin2, AuthorBaekvad-Hansen, Marie2, AuthorBeekman, Aartjan T. F.2, AuthorBigdeli, Tim B.2, AuthorBlackwood, Douglas H. R.2, AuthorBryois, Julien2, AuthorButtenschon, Henriette N.2, AuthorBybjerg-Grauholm, Jonas2, AuthorCai, Na2, AuthorCastelao, Enrique2, AuthorChristensen, Jane Hvarregaard2, AuthorClarke, Toni-Kim2, AuthorColeman I, Jonathan R.2, AuthorColodro-Conde, Lucia2, AuthorCouvy-Duchesne, Baptiste2, AuthorCraddock, Nick2, AuthorCrawford, Gregory E.2, AuthorDavies, Gail2, AuthorDeary, Ian J.2, AuthorDegenhardt, Franziska2, AuthorDerks, Eske M.2, AuthorDirek, Nese2, AuthorDolan V, Conor2, AuthorDunn, Erin C.2, AuthorEley, Thalia C.2, AuthorEscott-Price, Valentina2, AuthorKiadeh, Farnush Farhadi Hassan2, AuthorFinucane, Hilary K.2, AuthorForstner, Andreas J.2, AuthorFrank, Josef2, AuthorGaspar, Helena A.2, AuthorGill, Michael2, AuthorGoes, Fernando S.2, AuthorGordon, Scott D.2, AuthorGrove, Jakob2, AuthorHall, Lynsey S.2, AuthorHansen, Christine Soholm2, AuthorHansen, Thomas F.2, AuthorHerms, Stefan2, AuthorHickie, Ian B.2, AuthorHoffmann, Per2, AuthorHomuth, Georg2, AuthorHorn, Carsten2, AuthorHottenga, Jouke-Jan2, AuthorHougaard, David M.2, AuthorIsing, Marcus3, Author           Jansen, Rick2, AuthorJorgenson, Eric2, AuthorKnowles, James A.2, AuthorKohane, Isaac S.2, AuthorKraft, Julia2, AuthorKretzschmar, Warren W.2, AuthorKrogh, Jesper2, AuthorKutalik, Zoltan2, AuthorLi, Yihan2, AuthorLind, Penelope A.2, AuthorMacIntyre, Donald J.2, AuthorMacKinnon, Dean F.2, AuthorMaier, Robert M.2, AuthorMaier, Wolfgang2, AuthorMarchini, Jonathan2, AuthorMbarek, Hamdi2, AuthorMcGrath, Patrick2, AuthorMcGuffin, Peter2, AuthorMedland, Sarah E.2, AuthorMehta, Divya2, AuthorMiddeldorp, Christel M.2, AuthorMihailov, Evelin2, AuthorMilaneschi, Yuri2, AuthorMilani, Lili2, AuthorMondimore, Francis M.2, AuthorMontgomery, Grant W.2, AuthorMostafavi, Sara2, AuthorMullins, Niamh2, AuthorNauck, Matthias2, AuthorNg, Bernard2, AuthorNivard, Michel G.2, AuthorNyholt, Dale R.2, AuthorO'Reilly, Paul F.2, AuthorOskarsson, Hogni2, AuthorOwen, Michael J.2, AuthorPainter, Jodie N.2, AuthorPedersen, Carsten Bocker2, AuthorPedersen, Marianne Girtz2, AuthorPeterson, Roseann E.2, AuthorPettersson, Erik2, AuthorPeyrot, Wouter J.2, AuthorPistis, Giorgio2, AuthorPosthuma, Danielle2, AuthorQuiroz, Jorge A.2, AuthorQvist, Per2, AuthorRice, John P.2, AuthorRiley, Brien P.2, AuthorRivera, Margarita2, AuthorMirza, Saira Saeed2, AuthorSchoevers, Robert2, AuthorSchulte, Eva C.2, AuthorShen, Ling2, AuthorShi, Jianxin2, AuthorShyn I, Stanley2, AuthorSigurdsson, Engilbert2, AuthorSinnamon, Grant C. B.2, AuthorSmit, Johannes H.2, AuthorSmith, Daniel J.2, AuthorStefansson, Hreinn2, AuthorSteinberg, Stacy2, AuthorStreit, Fabian2, AuthorStrohmaier, Jana2, AuthorTansey, Katherine E.2, AuthorTeismann, Henning2, AuthorTeumer, Alexander2, AuthorThompson, Wesley2, AuthorThomson, Pippa A.2, AuthorThorgeirsson, Thorgeir E.2, AuthorTraylor, Matthew2, AuthorTreutlein, Jens2, AuthorTrubetskoy, Vassily2, AuthorUitterlinden, Andre G.2, AuthorUmbricht, Daniel2, AuthorVan der Auwera, Sandra2, Authorvan Hemert, Albert M.2, AuthorViktorin, Alexander2, AuthorVisscher, Peter M.2, AuthorWang, Yunpeng2, AuthorWebb, Bradley T.2, AuthorWeinsheimer, Shantel Marie2, AuthorWellmann, Juergen2, AuthorWillemsen, Gonneke2, AuthorWitt, Stephanie H.2, AuthorWu, Yang2, AuthorXi, Hualin S.2, AuthorYang, Jian2, AuthorZhang, Futao2, AuthorArolt, Volker2, AuthorBaune, Bernhard T.2, AuthorBerger, Klaus2, AuthorBoomsma I, Dorret2, AuthorCichon, Sven2, AuthorDannlowski, Udo2, Authorde Geus, E. J. C.2, AuthorDePaulo, J. Raymond2, AuthorDomenici, Enrico2, AuthorDomschke, Katharina2, AuthorEsko, Tonu2, AuthorGrabe, Hans J.2, AuthorHamilton, Steven P.2, AuthorHayward, Caroline2, AuthorHeath, Andrew C.2, AuthorKendler, Kenneth S.2, AuthorKloiber, Stefan3, Author           Lewis, Glyn2, AuthorLi, Qingqin S.2, AuthorLucae, Susanne3, Author           Madden, Pamela A. F.2, AuthorMagnusson, Patrik K.2, AuthorMartin, Nicholas G.2, AuthorMcIntosh, Andrew M.2, AuthorMetspalu, Andres2, AuthorMors, Ole2, AuthorMortensen, Preben Bo2, AuthorMueller-Myhsok, Bertram4, Author           Nordentoft, Merete2, AuthorNoethen, Markus M.2, AuthorO'Donovan, Michael C.2, AuthorPaciga, Sara A.2, AuthorPedersen, Nancy L.2, AuthorPenninx, Brenda W. J. H.2, AuthorPerlis, Roy H.2, AuthorPorteous, David J.2, AuthorPotash, James B.2, AuthorPreisig, Martin2, AuthorRietschel, Marcella2, AuthorSchaefer, Catherine2, AuthorSchulze, Thomas G.2, AuthorSmoller, Jordan W.2, AuthorStefansson, Kari2, AuthorTiemeier, Henning2, AuthorUher, Rudolf2, AuthorVoelzke, Henry2, AuthorWeissman, Myrna M.2, AuthorWerge, Thomas2, AuthorLewis, Cathryn M.2, AuthorLevinson, Douglas F.2, AuthorBreen, Gerome2, AuthorBorglum, Anders D.2, AuthorSullivan, Patrick F.2, Author more..
Affiliations:
1Dept. Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Max Planck Society, ou_2035295              
2external, ou_persistent22              
3Max Planck Institute of Psychiatry, Max Planck Society, ou_1607137              
4RG Statistical Genetics, Max Planck Institute of Psychiatry, Max Planck Society, ou_2040288              

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 Abstract: Epigenetic processes, including DNA methylation (DNAm), are among the mechanisms allowing integration of genetic and environmental factors to shape cellular function. While many studies have investigated either environmental or genetic contributions to DNAm, few have assessed their integrated effects. Here we examine the relative contributions of prenatal environmental factors and genotype on DNA methylation in neonatal blood at variably methylated regions (VMRs) in 4 independent cohorts (overall n = 2365). We use Akaike's information criterion to test which factors best explain variability of methylation in the cohort-specific VMRs: several prenatal environmental factors (E), genotypes in cis (G), or their additive (G + E) or interaction (GxE) effects. Genetic and environmental factors in combination best explain DNAm at the majority of VMRs. The CpGs best explained by either G, G + E or GxE are functionally distinct. The enrichment of genetic variants from GxE models in GWAS for complex disorders supports their importance for disease risk.

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 Dates: 2019
 Publication Status: Published online
 Pages: -
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 Table of Contents: -
 Rev. Type: -
 Identifiers: ISI: 000470968400008
DOI: 10.1038/s41467-019-10461-0
 Degree: -

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Title: NATURE COMMUNICATIONS
Source Genre: Journal
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Pages: - Volume / Issue: 10 Sequence Number: 2548 Start / End Page: - Identifier: ISSN: 2041-1723