English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Peritraumatic Neural Processing and Intrusive Memories: The Role of Lifetime Adversity

Rattel, J. A., Miedl, S. F., Franke, L. K., Gruenberger, L. M., Blechert, J., Kronbichler, M., et al. (2019). Peritraumatic Neural Processing and Intrusive Memories: The Role of Lifetime Adversity. BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING, 4(4), 381-389. doi:10.1016/j.bpsc.2018.12.010.

Item is

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Rattel, Julina A., Author
Miedl, Stephan F., Author
Franke, Laila K., Author
Gruenberger, Lisa M., Author
Blechert, Jens, Author
Kronbichler, Martin, Author
Spoormaker, Victor I.1, Author           
Wilhelm, Frank H., Author
Affiliations:
1Dept. Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Max Planck Society, ou_2035295              

Content

show
hide
Free keywords: -
 Abstract: BACKGROUND: Pathological peritraumatic encoding is proposed as a proximal risk factor for the development of posttraumatic stress disorder (PTSD), with trauma-analog studies linking increased neural processing of trauma films to intrusive trauma recollections, a core symptom of PTSD. Cumulative lifetime adversity is proposed as a more distal risk factor, with research indicating a tipping point at about five events with regard to PTSD development following re-exposure to trauma. Thus, within a diathesis x stress framework, increased peritraumatic neural processing may constitute a specific risk factor for PTSD, particularly in individuals with several lifetime adversities.
METHODS: Fifty-three healthy women watched highly aversive films depicting severe interpersonal violence versus neutral films during functional magnetic resonance imaging, and they reported involuntary recollections during subsequent days. Moderation analyses tested the interactive relationship between peritraumatic neural processing and lifetime adversity in predicting intrusion load, i.e., the total number of intrusions weighted for their average distress.
RESULTS: Increased processing of aversive versus neutral films in the amygdala, anterior insula, dorsal and rostral anterior cingulate cortices, and hippocampus predicted increased intrusion load only in participants reporting above five lifetime adversities; for participants reporting few to none, no such relationship was found. This interactive relationship explained 59% of variance. Conditioned stimuli preceding film viewing mirrored this pattern.
CONCLUSIONS: Peritraumatic neural processing in multiple salience network regions and cumulative lifetime adversity interactively predicted PTSD-like symptomatology, representing a diathesis x stress framework that might guide identification of at-risk individuals and potential targets for symptom prevention after traumatic incidents.

Details

show
hide
Language(s):
 Dates: 2019
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 4 (4) Sequence Number: - Start / End Page: 381 - 389 Identifier: ISSN: 2451-9022