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  A longitudinal approach to biological psychiatric research: The PsyCourse study

Budde, M., Anderson-Schmidt, H., Gade, K., Reich-Erkelenz, D., Adorjan, K., Kalman, J. L., et al. (2019). A longitudinal approach to biological psychiatric research: The PsyCourse study. SI, 180(2), 89-102. doi:10.1002/ajmg.b.32639.

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Budde, Monika, Author
Anderson-Schmidt, Heike, Author
Gade, Katrin, Author
Reich-Erkelenz, Daniela, Author
Adorjan, Kristina, Author
Kalman, Janos L.1, Author           
Senner, Fanny, Author
Papiol, Sergi, Author
Andlauer, Till F. M.2, Author           
Comes, Ashley L.1, Author           
Schulte, Eva C., Author
Kloehn-Saghatolislam, Farah, Author
Gryaznova, Anna, Author
Hake, Maria, Author
Bartholdi, Kim, Author
Flatau, Laura, Author
Reitt, Markus, Author
Quast, Silke, Author
Stegmaier, Sophia, Author
Meyers, Milena, Author
Emons, Barbara, AuthorHaussleiter, Ida Sybille, AuthorJuckel, Georg, AuthorNieratschker, Vanessa, AuthorDannlowski, Udo, AuthorSchaupp, Sabrina K., AuthorSchmauss, Max, AuthorZimmermann, Joerg, AuthorReimer, Jens, AuthorSchulz, Sybille, AuthorWiltfang, Jens, AuthorReininghaus, Eva, AuthorAnghelescu, Ion-George, AuthorArolt, Volker, AuthorBaune, Bernhard T., AuthorKonrad, Carsten, AuthorThiel, Andreas, AuthorFallgatter, Andreas J., AuthorFigge, Christian, Authorvon Hagen, Martin, AuthorKoller, Manfred, AuthorLang, Fabian U., AuthorWigand, Moritz E., AuthorBecker, Thomas, AuthorJaeger, Markus, AuthorDietrich, Detlef E., AuthorStierl, Sebastian, AuthorScherk, Harald, AuthorSpitzer, Carsten, AuthorFolkerts, Here, AuthorWitt, Stephanie H., AuthorDegenhardt, Franziska, AuthorForstner, Andreas J., AuthorRietschel, Marcella, AuthorNoethen, Markus M., AuthorFalkai, Peter, AuthorSchulze, Thomas G., AuthorHeilbronner, Urs, Author more..
Affiliations:
1IMPRS Translational Psychiatry, Max Planck Institute of Psychiatry, Max Planck Society, ou_3318616              
2Dept. Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Max Planck Society, ou_2035295              

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 Abstract: In current diagnostic systems, schizophrenia and bipolar disorder are still conceptualized as distinct categorical entities. Recently, both clinical and genomic evidence have challenged this Kraepelinian dichotomy. There are only few longitudinal studies addressing potential overlaps between these conditions. Here, we present design and first results of the PsyCourse study (N = 891 individuals at baseline), an ongoing transdiagnostic study of the affective-to-psychotic continuum that combines longitudinal deep phenotyping and dimensional assessment of psychopathology with an extensive collection of biomaterial. To provide an initial characterization of the PsyCourse study sample, we compare two broad diagnostic groups defined by the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) classification system, that is, predominantly affective (n = 367 individuals) versus predominantly psychotic disorders (n = 524 individuals). Depressive, manic, and psychotic symptoms as well as global functioning over time were contrasted using linear mixed models. Furthermore, we explored the effects of polygenic risk scores for schizophrenia on diagnostic group membership and addressed their effects on nonparticipation in follow-up visits. While phenotypic results confirmed expected differences in current psychotic symptoms and global functioning, both manic and depressive symptoms did not vary between both groups after correction for multiple testing. Polygenic risk scores for schizophrenia significantly explained part of the variability of diagnostic group. The PsyCourse study presents a unique resource to research the complex relationships of psychopathology and biology in severe mental disorders not confined to traditional diagnostic boundaries and is open for collaborations.

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 Dates: 2019
 Publication Status: Published in print
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 Rev. Type: -
 Identifiers: ISI: 000459452000001
DOI: 10.1002/ajmg.b.32639
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Title: SI
Source Genre: Issue
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Pages: - Volume / Issue: 180 (2) Sequence Number: - Start / End Page: 89 - 102 Identifier: ISSN: 1552-4841

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Title: AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
Source Genre: Journal
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Pages: - Volume / Issue: 180 Sequence Number: - Start / End Page: - Identifier: -