English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
 
 
DownloadE-Mail
  Genome-wide association scan identifies new variants associated with a cognitive predictor of dyslexia

Gialluisi, A., Andlauer, T. F. M., Mirza-Schreiber, N., Moll, K., Becker, J., Hoffmann, P., et al. (2019). Genome-wide association scan identifies new variants associated with a cognitive predictor of dyslexia. TRANSLATIONAL PSYCHIATRY, 9: 77. doi:10.1038/s41398-019-0402-0.

Item is

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Gialluisi, Alessandro1, Author           
Andlauer, Till F. M.1, Author           
Mirza-Schreiber, Nazanin2, Author           
Moll, Kristina, Author
Becker, Jessica, Author
Hoffmann, Per, Author
Ludwig, Kerstin U., Author
Czamara, Darina1, Author           
St Pourcain, Beate, Author
Brandler, William, Author
Honbolygo, Ferenc, Author
Toth, Denes, Author
Csepe, Valeria, Author
Huguet, Guillaume, Author
Morris, Andrew P., Author
Hulslander, Jacqueline, Author
Willcutt, Erik G., Author
DeFries, John C., Author
Olson, Richard K., Author
Smith, Shelley D., Author
Pennington, Bruce F., AuthorVaessen, Anniek, AuthorMaurer, Urs, AuthorLyytinen, Heikki, AuthorPeyrard-Janvid, Myriam, AuthorLeppanen, Paavo H. T., AuthorBrandeis, Daniel, AuthorBonte, Milene, AuthorStein, John F., AuthorTalcott, Joel B., AuthorFauchereau, Fabien, AuthorWilcke, Arndt, AuthorFrancks, Clyde, AuthorBourgeron, Thomas, AuthorMonaco, Anthony P., AuthorRamus, Franck, AuthorLanderl, Karin, AuthorKere, Juha, AuthorScerri, Thomas S., AuthorParacchini, Silvia, AuthorFisher, Simon E., AuthorSchumacher, Johannes, AuthorNoethen, Markus M., AuthorMueller-Myhsok, Bertram2, Author           Schulte-Koerne, Gerd, Author more..
Affiliations:
1Dept. Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Max Planck Society, ou_2035295              
2RG Statistical Genetics, Max Planck Institute of Psychiatry, Max Planck Society, ou_2040288              

Content

show
hide
Free keywords: -
 Abstract: Developmental dyslexia (DD) is one of the most prevalent learning disorders, with high impact on school and psychosocial development and high comorbidity with conditions like attention-deficit hyperactivity disorder (ADHD), depression, and anxiety. DD is characterized by deficits in different cognitive skills, including word reading, spelling, rapid naming, and phonology. To investigate the genetic basis of DD, we conducted a genome-wide association study (GWAS) of these skills within one of the largest studies available, including nine cohorts of reading-impaired and typically developing children of European ancestry (N = 2562-3468). We observed a genome-wide significant effect (p < 1 x 10(-8)) on rapid automatized naming of letters (RANlet) for variants on 18q12.2, within MIR924HG (micro-RNA 924 host gene; rs17663182 p = 4.73 x 10(-9)), and a suggestive association on 8q12.3 within NKAIN3 (encoding a cation transporter; rs16928927, p = 2.25 x 10(-8)). rs17663182 (18q12.2) also showed genome-wide significant multivariate associations with RAN measures (p = 1.15 x 10(-8)) and with all the cognitive traits tested (p = 3.07 x 10(-8)), suggesting (relational) pleiotropic effects of this variant. A polygenic risk score (PRS) analysis revealed significant genetic overlaps of some of the DD-related traits with educational attainment (EDUyears) and ADHD. Reading and spelling abilities were positively associated with EDUyears (p similar to [10(-5)-10(-7)]) and negatively associated with ADHD PRS (p similar to [10(-8)-10(-17)]). This corroborates a long-standing hypothesis on the partly shared genetic etiology of DD and ADHD, at the genome-wide level. Our findings suggest new candidate DD susceptibility genes and provide new insights into the genetics of dyslexia and its comorbities.

Details

show
hide
Language(s):
 Dates: 2019
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: ISI: 000459834900001
DOI: 10.1038/s41398-019-0402-0
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: TRANSLATIONAL PSYCHIATRY
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 9 Sequence Number: 77 Start / End Page: - Identifier: ISSN: 2158-3188