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  Structural plasticity of the selectivity filter in a nonselective ion channel

Roy, R. N., Hendriks, K., Kopec, W., Abdolvand, S., Weiss, K. L., de Groot, B. L., et al. (2021). Structural plasticity of the selectivity filter in a nonselective ion channel. IUCrJ, 8(3), 421-430. doi:10.1107/S205225252100213X.

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 Creators:
Roy, R. N., Author
Hendriks, K., Author
Kopec, W.1, Author              
Abdolvand, S., Author
Weiss, K. L., Author
de Groot, B. L.1, Author              
Lange, A., Author
Sun, H., Author
Coates, L., Author
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1Research Group of Computational Biomolecular Dynamics, MPI for biophysical chemistry, Max Planck Society, ou_578573              

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Free keywords: ion channels; membrane proteins; X-ray crystallography; solid-state NMR; molecular dynamics.
 Abstract: The sodium potassium ion channel (NaK) is a nonselective ion channel that conducts both sodium and potassium across the cellular membrane. A new crystallographic structure of NaK reveals conformational differences in the residues that make up the selectivity filter between the four subunits that form the ion channel and the inner helix of the ion channel. The crystallographic structure also identifies a side-entry, ion-conduction pathway for Na+ permeation that is unique to NaK. NMR studies and molecular dynamics simulations confirmed the dynamical nature of the top part of the selectivity filter and the inner helix in NaK as also observed in the crystal structure. Taken together, these results indicate that the structural plasticity of the selectivity filter combined with the dynamics of the inner helix of NaK are vital for the efficient conduction of different ions through the non-selective ion channel of NaK.

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Language(s): eng - English
 Dates: 2021-05
 Publication Status: Published online
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 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1107/S205225252100213X
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Title: IUCrJ
Source Genre: Journal
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Pages: - Volume / Issue: 8 (3) Sequence Number: - Start / End Page: 421 - 430 Identifier: -