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  Deuterium Metabolic Imaging in the human brain at 9.4 Tesla with high spatial and temporal resolution

Ruhm, L., Avdievich, N., Ziegs, T., Nagel, A., De Feyter, H., de Graaf, R., et al. (2021). Deuterium Metabolic Imaging in the human brain at 9.4 Tesla with high spatial and temporal resolution. NeuroImage, 244: 118639, pp. 1-12. doi:10.1016/j.neuroimage.2021.118639.

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Ruhm, L1, 2, Author              
Avdievich, NI2, 3, Author              
Ziegs, T1, Author              
Nagel, AM, Author
De Feyter , HM, Author
de Graaf, RA, Author
Henning, A1, 2, Author              
Affiliations:
1Research Group MR Spectroscopy and Ultra-High Field Methodology, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_2528692              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              
3Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497796              

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 Abstract: Purpose: To present first highly spatially resolved deuterium metabolic imaging (DMI) measurements of the human brain acquired with a dedicated coil design and a fast chemical shift imaging (CSI) sequence at an ultrahigh field strength of B0 = 9.4 T. 2H metabolic measurements with a temporal resolution of 10 min enabled the investigation of the glucose metabolism in healthy human subjects. Methods: The study was performed with a double-tuned coil with 10 TxRx channels for 1H and 8TxRx/2Rx channels for 2H and an Ernst angle 3D CSI sequence with a nominal spatial resolution of 2.97 ml and a temporal resolution of 10 min. Results: The metabolism of [6,6'-2H2]-labeled glucose due to the TCA cycle could be made visible in high resolution metabolite images of deuterated water, glucose and Glx over the entire human brain. Conclusion: X-nuclei MRSI as DMI can highly benefit from ultrahigh field strength enabling higher temporal and spatial resolutions.

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 Dates: 2021-102021-12
 Publication Status: Published in print
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 Identifiers: DOI: 10.1016/j.neuroimage.2021.118639
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Title: NeuroImage
Source Genre: Journal
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Publ. Info: Orlando, FL : Academic Press
Pages: - Volume / Issue: 244 Sequence Number: 118639 Start / End Page: 1 - 12 Identifier: ISSN: 1053-8119
CoNE: https://pure.mpg.de/cone/journals/resource/954922650166