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  Effects of hippocampal interictal discharge timing, duration, and spatial extent on list learning

Leeman-Markowski, B., Hardstone, R., Lohnas, L., Cowen, B., Davachi, L., Doyle, W., et al. (2021). Effects of hippocampal interictal discharge timing, duration, and spatial extent on list learning. Epilepsy & behavior, 123: 108209. doi:10.1016/j.yebeh.2021.108209.

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 Creators:
Leeman-Markowski, Beth1, 2, Author
Hardstone, Richard3, Author
Lohnas, Lynn4, Author
Cowen, Benjamin5, Author
Davachi, Lila4, Author
Doyle, Werner6, Author
Dugan, Patricia2, Author
Friedman, Daniel2, Author
Anli, Liu2, 3, Author
Melloni, Lucia2, 7, Author           
Selesnick, Ivan5, Author
Wang, Binhuan8, Author
Meador, Kimford9, Author
Devinsky, Orrin2, 3, 6, 10, Author
Affiliations:
1Research Service, VA New York Harbor Healthcare System, 423 E. 23rd St., New York, NY 10010, United States, ou_persistent22              
2Comprehensive Epilepsy Center, Department of Neurology, New York University Langone Health, 223 E. 34th St., New York, NY 10016, United States, ou_persistent22              
3Neuroscience Institute, New York University Langone Health, 550 1st Ave., New York, NY 10016, United States, ou_persistent22              
4Department of Psychology, New York University, 6 Washington Pl., New York, NY 10003, United States, ou_persistent22              
5Department of Electrical and Computer Engineering, Tandon School of Engineering, New York University, 6 MetroTech Center, Brooklyn, NY 11201, United States, ou_persistent22              
6Department of Neurosurgery, New York University Langone Health, 530 1st Ave., New York, NY 10016, United States, ou_persistent22              
7Department of Neuroscience, Max Planck Institute for Empirical Aesthetics, Max Planck Society, ou_2421697              
8Department of Population Health, New York University Langone Health, 180 Madison Ave., New York, NY 10016, United States, ou_persistent22              
9Department of Neurology & Neurological Sciences, Stanford University School of Medicine, 213 Quarry Road, Palo Alto, CA 94304, United States, ou_persistent22              
10Department of Psychiatry, New York University Langone Health, 550 1st Ave., New York, NY 10016, United States, ou_persistent22              

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Free keywords: Electrocorticography Intracranial EEG Intracranial electroencephalography EEG Memory Learning
 Abstract: Interictal epileptiform discharges (IEDs) can impair memory. The properties of IEDs most detrimental to memory, however, are undefined. We studied the impact of temporal and spatial characteristics of IEDs on list learning. Subjects completed a memory task during intracranial EEG recordings including hippocampal depth and temporal neocortical subdural electrodes. Subjects viewed a series of objects, and after a distracting task, recalled the objects from the list. The impacts of IED presence, duration, and propagation to neocortex during encoding of individual stimuli were assessed. The effects of IED total number and duration during maintenance and recall periods on delayed recall performance were also determined. The influence of IEDs during recall was further investigated by comparing the likelihood of IEDs preceding correctly recalled items vs. periods of no verbal response. Across 6 subjects, we analyzed 28 hippocampal and 139 lateral temporal contacts. Recall performance was poor, with a median of 17.2% correct responses (range 10.4–21.9%). Interictal epileptiform discharges during encoding, maintenance, and recall did not significantly impact task performance, and there was no significant difference between the likelihood of IEDs during correct recall vs. periods of no response. No significant effects of discharge duration during encoding, maintenance, or recall were observed. Interictal epileptiform discharges with spread to lateral temporal cortex during encoding did not adversely impact recall. A post hoc analysis refining model assumptions indicated a negative impact of IED count during the maintenance period, but otherwise confirmed the above results. Our findings suggest no major effect of hippocampal IEDs on list learning, but study limitations, such as baseline hippocampal dysfunction, should be considered. The impact of IEDs during the maintenance period may be a focus of future research.

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Language(s): eng - English
 Dates: 2021-05-112021-02-122021-06-302021-08-172021-10
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1016/j.yebeh.2021.108209
 Degree: -

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Title: Epilepsy & behavior
Source Genre: Journal
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Publ. Info: New York, NY : Elsevier
Pages: - Volume / Issue: 123 Sequence Number: 108209 Start / End Page: - Identifier: ISSN: 1525-5050
ISSN: 1525-5069