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  An overview of the synaptic vesicle lipid composition

Binotti, B., Jahn, R., & Pérez-Lara, A. (2021). An overview of the synaptic vesicle lipid composition. Archives of Biochemistry and Biophysics, 709: 108966. doi:10.1016/j.abb.2021.108966.

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Binotti, B., Author
Jahn, R.1, Author              
Pérez-Lara, A., Author
Affiliations:
1Laboratory of Neurobiology, Max Planck Institute for Biophysical Chemistry, Max Planck Society, ou_3049887              

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Free keywords: Lipid composition; Synaptic vesicles; Neurotransmitter release; Exocytosis; Endocytosis
 Abstract: Chemical neurotransmission is the major mechanism of neuronal communication. Neurotransmitters are released from secretory organelles, the synaptic vesicles (SVs) via exocytosis into the synaptic cleft. Fusion of SVs with the presynaptic plasma membrane is balanced by endocytosis, thus maintaining the presynaptic membrane at steady-state levels. The protein machineries responsible for exo- and endocytosis have been extensively investigated. In contrast, less is known about the role of lipids in synaptic transmission and how the lipid composition of SVs is affected by dynamic exo-endocytotic cycling. Here we summarize the current knowledge about the composition, organization, and function of SV membrane lipids. We also cover lipid biogenesis and maintenance during the synaptic vesicle cycle.

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Language(s): eng - English
 Dates: 2021-06-152021-09-30
 Publication Status: Published in print
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 Rev. Type: Peer
 Identifiers: DOI: 10.1016/j.abb.2021.108966
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Title: Archives of Biochemistry and Biophysics
Source Genre: Journal
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Pages: 8 Volume / Issue: 709 Sequence Number: 108966 Start / End Page: - Identifier: -