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  Going to extremes: A metagenomic journey into the dark matter of life

Aevarsson, A., Kaczorowska, A.-K., Adalsteinsson, B. T., Ahlqvist, J., Al-Karadaghi, S., Altenbuchner, J., et al. (2021). Going to extremes: A metagenomic journey into the dark matter of life. FEMS Microbiology Letters, 368(12): fnab067. doi:10.1093/femsle/fnab067.

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Aevarsson, A., Author
Kaczorowska, A.-K., Author
Adalsteinsson, B. T., Author
Ahlqvist, J., Author
Al-Karadaghi, S., Author
Altenbuchner, J., Author
Arsin, H., Author
Átlasson, Ú. Á., Author
Brandt, D., Author
Cichowicz-Cieślak, M., Author
Cornish, K. A. S., Author
Courtin, J., Author
Dabrowski, S., Author
Dahle, H., Author
Djeffane, S., Author
Dorawa, S., Author
Dusaucy, J., Author
Enault, F., Author
Fedøy, A.-E., Author
Freitag-Pohl, S., Author
Fridjonsson, O. H., AuthorGaliez, C., AuthorGlomsaker, E., AuthorGuérin, M., AuthorGundesø, S. E., AuthorGudmundsdóttir, E. E., AuthorGudmundsson, H., AuthorHåkansson, M., AuthorHenke, C., AuthorHelleux, A., AuthorHenriksen, J. R., AuthorHjörleifdóttir, S., AuthorHreggvidsson, G. O., AuthorJasilionis, A., AuthorJochheim, A.1, Author              Jónsdóttir, I., AuthorJónsdóttir, L. B., AuthorJurczak-Kurek, A., AuthorKaczorowski, T., AuthorKalinowski, J., AuthorKozlowski, L. P., AuthorKrupovic, M., AuthorKwiatkowska-Semrau, K., AuthorLanes, O., AuthorLange, J., AuthorLebrat, J., AuthorLinares-Pastén, J., AuthorLiu, Y., AuthorLorentsen, S. A., AuthorLutterman, T., AuthorMas, T., AuthorMerré, W., AuthorMirdita, M.1, Author              Morzywołek, A., AuthorNdela, E. O., AuthorKarlsson, E. N., AuthorOlgudóttir, E., AuthorPedersen, C., AuthorPerler, F., AuthorPétursdóttir, S. K., AuthorPlotka, M., AuthorPohl, E., AuthorPrangishvili, D., AuthorRay, J. L., AuthorReynisson, B., AuthorRóbertsdóttir, T., AuthorSandaa, R.-A., AuthorSczyrba, A., AuthorSkírnisdóttir, S, AuthorSöding, J.1, Author              Solstad, T., AuthorSteen, I. H., AuthorStefánsson, S. K., AuthorSteinegger, M., AuthorOverå, K. S., AuthorStriberny, B., AuthorSvensson, A., AuthorSzadkowska, M., AuthorTarrant, J., AuthorTerzian, P., AuthorTourigny, M., Authorvan den Bergh, T., AuthorVanhalst, J., AuthorVincent, J., AuthorVroling, B., AuthorWalse, B., AuthorWang, L., AuthorWatzlawick, H., AuthorWelin, M., AuthorWerbowy, O., AuthorWons, E., AuthorZhang, R., Author more..
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1Research Group of Computational Biology, MPI for Biophysical Chemistry, Max Planck Society, ou_1933286              

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Free keywords: virus, virosphere, archaea, metagenomics, bioprospecting, thermophiles
 Abstract: The Virus-X—Viral Metagenomics for Innovation Value—project was a scientific expedition to explore and exploit uncharted territory of genetic diversity in extreme natural environments such as geothermal hot springs and deep-sea ocean ecosystems. Specifically, the project was set to analyse and exploit viral metagenomes with the ultimate goal of developing new gene products with high innovation value for applications in biotechnology, pharmaceutical, medical, and the life science sectors. Viral gene pool analysis is also essential to obtain fundamental insight into ecosystem dynamics and to investigate how viruses influence the evolution of microbes and multicellular organisms. The Virus-X Consortium, established in 2016, included experts from eight European countries. The unique approach based on high throughput bioinformatics technologies combined with structural and functional studies resulted in the development of a biodiscovery pipeline of significant capacity and scale. The activities within the Virus-X consortium cover the entire range from bioprospecting and methods development in bioinformatics to protein production and characterisation, with the final goal of translating our results into new products for the bioeconomy. The significant impact the consortium made in all of these areas was possible due to the successful cooperation between expert teams that worked together to solve a complex scientific problem using state-of-the-art technologies as well as developing novel tools to explore the virosphere, widely considered as the last great frontier of life

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Language(s): eng - English
 Dates: 2021-06-11
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1093/femsle/fnab067
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Title: FEMS Microbiology Letters
Source Genre: Journal
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Pages: 16 Volume / Issue: 368 (12) Sequence Number: fnab067 Start / End Page: - Identifier: -