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  Genetic Instability Due to Spindle Anomalies Visualized in Mutants of Dictyostelium

Ecke, M., Prassler, J., & Gerisch, G. (2021). Genetic Instability Due to Spindle Anomalies Visualized in Mutants of Dictyostelium. Cells, 10(9): 2240. doi:10.3390/cells10092240.

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 Creators:
Ecke, Mary1, Author              
Prassler, Jana1, Author              
Gerisch, Günther1, Author              
Affiliations:
1Gerisch, Günther / Cell Dynamics, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565149              

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Free keywords: BINDING PROTEINS; CENTROSOME; ACTIN; DYNAMICS; ORGANIZATION; MEMBRANE; CELLSCell Biology; centrosomes; chromosome segregation; Dictyostelium; genetic instability; mitosis; multinucleate cells;
 Abstract: Aberrant centrosome activities in mutants of Dictyostelium discoideum result in anomalies of mitotic spindles that affect the reliability of chromosome segregation. Genetic instabilities caused by these deficiencies are tolerated in multinucleate cells, which can be produced by electric-pulse induced cell fusion as a source for aberrations in the mitotic apparatus of the mutant cells. Dual-color fluorescence labeling of the microtubule system and the chromosomes in live cells revealed the variability of spindle arrangements, of centrosome-nuclear interactions, and of chromosome segregation in the atypical mitoses observed.

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Language(s): eng - English
 Dates: 2021
 Publication Status: Published online
 Pages: 14
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: ISI: 000699415800001
DOI: 10.3390/cells10092240
 Degree: -

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Title: Cells
Source Genre: Journal
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Publ. Info: Basel, Switzerland : MDPI
Pages: - Volume / Issue: 10 (9) Sequence Number: 2240 Start / End Page: - Identifier: CoNE: https://pure.mpg.de/cone/journals/resource/2073-4409