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  Connectivity alterations in autism reflect functional idiosyncrasy

Benkarim, O., Paquola, C., Park, B.-y., Hong, S.-J., Royer, J., Vos de Wael, R., et al. (2021). Connectivity alterations in autism reflect functional idiosyncrasy. Communications Biology, 4: 1078. doi:10.1038/s42003-021-02572-6.

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 Creators:
Benkarim, Oualid1, Author
Paquola, Casey1, Author
Park, Bo-yong1, Author
Hong, Seok-Jun2, 3, 4, Author
Royer, Jessica1, Author
Vos de Wael, Reinder1, Author
Lariviere, Sara1, Author
Valk, Sofie L.5, 6, Author           
Bzdok, Danilo1, 7, 8, Author
Mottron, Laurent9, Author
C. Bernhardt, Boris1, Author
Affiliations:
1McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, QC, Canada, ou_persistent22              
2Center for the Developing Brain, Child Mind Institute, New York, NY, USA, ou_persistent22              
3Center for Neuroscience Imaging Research, Sungkyunkwan University, Seoul, Republic of Korea, ou_persistent22              
4Department of Biomedical Engineering, Sungkyunkwan University, Seoul, Republic of Korea, ou_persistent22              
5Otto Hahn Group Cognitive Neurogenetics, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_3222264              
6Institute of Neuroscience and Medicine, Research Center Jülich, Germany, ou_persistent22              
7Department of Biomedical Engineering, McGill University, Montréal, QC, Canada, ou_persistent22              
8Mila – Quebec Artificial Intelligence Institute, Montréal, QC, Canada, ou_persistent22              
9Department of Psychiatry, University of Montréal, QC, Canada, ou_persistent22              

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 Abstract: Autism spectrum disorder (ASD) is commonly understood as an alteration of brain networks, yet case-control analyses against typically-developing controls (TD) have yielded inconsistent results. Here, we devised a novel approach to profile the inter-individual variability in functional network organization and tested whether such idiosyncrasy contributes to connectivity alterations in ASD. Studying a multi-centric dataset with 157 ASD and 172 TD, we obtained robust evidence for increased idiosyncrasy in ASD relative to TD in default mode, somatomotor and attention networks, but also reduced idiosyncrasy in lateral temporal cortices. Idiosyncrasy increased with age and significantly correlated with symptom severity in ASD. Furthermore, while patterns of functional idiosyncrasy were not correlated with ASD-related cortical thickness alterations, they co-localized with the expression patterns of ASD risk genes. Notably, we could demonstrate that patterns of atypical idiosyncrasy in ASD closely overlapped with connectivity alterations that are measurable with conventional case-control designs and may, thus, be a principal driver of inconsistency in the autism connectomics literature. These findings support important interactions between inter-individual heterogeneity in autism and functional signatures. Our findings provide novel biomarkers to study atypical brain development and may consolidate prior research findings on the variable nature of connectome level anomalies in autism.

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 Dates: 2021-02-222021-08-172021-09-15
 Publication Status: Published online
 Pages: -
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 Identifiers: DOI: 10.1038/s42003-021-02572-6
PMID: 34526654
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Grant ID : NRF-2020R1A6A3A03037088
Funding program : -
Funding organization : National Research Foundation of Korea
Project name : -
Grant ID : 1304413
Funding program : -
Funding organization : National Science and Engineering Research Council of Canada
Project name : -
Grant ID : CIHR FDN-154298
Funding program : -
Funding organization : Canadian Institutes of Health Research
Project name : -
Grant ID : NI17-039
Funding program : -
Funding organization : SickKids Foundation

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Title: Communications Biology
Source Genre: Journal
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Publ. Info: London : Springer Nature
Pages: - Volume / Issue: 4 Sequence Number: 1078 Start / End Page: - Identifier: ISSN: 2399-3642
CoNE: https://pure.mpg.de/cone/journals/resource/2399-3642