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  Automated synthesis of chondroitin sulfate oligosaccharides

Liang, C.-F., Hahm, H. S., Sabbavarapu, N. M., & Seeberger, P. H. (2022). Automated synthesis of chondroitin sulfate oligosaccharides. Methods in Molecular Biology, 2303, 319-327. doi:10.1007/978-1-0716-1398-6_26.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0009-6269-3 Version Permalink: https://hdl.handle.net/21.11116/0000-0009-626A-2
Genre: Journal Article

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Article.pdf (Publisher version), 411KB
 
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 Creators:
Liang , Chien-Fu1, Author
Hahm, Heung Sik1, Author           
Sabbavarapu, Narayana Murthy2, Author           
Seeberger, Peter H.1, Author           
Affiliations:
1Peter H. Seeberger - Automated Systems, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863306              
2Peter H. Seeberger - Vaccine Development, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863308              

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Free keywords: Glycosaminoglycans; Automated solid phase oligosaccharide synthesis; Photolabile linker; Chondroitin sulfate; N-acetyl-β-D-galactosamine; β-D-glucuronic acid
 Abstract: Glycosaminoglycans (GAGs) are important sulfated carbohydrates prevalently found in the extracellular matrix that serve many biological functions. The synthesis of structurally diverse but defined GAGs is extremely challenging as one has to account for the various sulfation patterns. Described is the automated synthesis of chondroitin sulfate hexasaccharides on a solid support equipped with a photolabile linker. The linker cleavage from the resin is performed in a continuous-flow photoreactor under chemically mild conditions. This approach serves as a general scheme to access oligosaccharides of all GAG families.

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Language(s): eng - English
 Dates: 2021-10-102022
 Publication Status: Issued
 Pages: -
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 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1007/978-1-0716-1398-6_26
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Title: Methods in Molecular Biology
  Other : Methods Mol. Biol.
Source Genre: Journal
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Publ. Info: Cham : Springer Nature Switzerland
Pages: - Volume / Issue: 2303 Sequence Number: - Start / End Page: 319 - 327 Identifier: ISSN: 1064-3745

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Title: Glycosaminoglycans : Methods and Protocols
Source Genre: Book
 Creator(s):
Balagurunathan, Kuberan, Editor
Nakato, Hiroshi, Editor
Desai, Umesh, Editor
Saijoh, Yukio, Editor
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Publ. Info: New York : Humana
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: - Identifier: ISBN: 978-1-0716-1397-9